The Role of MicroRNAs and Their Targets in Osteoarthritis.
Sondag. Gregory R GR; Haqqi. Tariq M TM
Key Findings
- MicroRNAs are involved in inflammation, obesity, autophagy, and cartilage health in osteoarthritis.
- Many microRNAs are differently expressed in osteoarthritis, but many of their targets are still unknown.
- MicroRNAs could become therapeutic targets or be modulated by certain remedies, but no concrete protocols are provided.
Practical Outcomes
- There’s no actionable advice for using humanin or other biohacks; the review is mainly basic science about osteoarthritis mechanisms.
Summary
The paper reviews how tiny RNA molecules called microRNAs affect osteoarthritis, but it doesn’t mention the peptide humanin or give any tips you can use for health hacking.
Abstract
Micro ribonucleic acid (microRNA) regulation and expression has become an emerging field in determining the mechanisms regulating a variety of inflammation-mediated diseases. Several studies have focused on specific microRNAs that are differentially expressed in cases of osteoarthritis. Furthermore, several targets of these miRNAs important in disease progression have also been identified. In this review, we focus on microRNA biogenesis, regulation, detection, and quantification with an emphasis on cellular localization and how these concepts may be linked to disease processes such as osteoarthritis. Next, we review the relationships of specific microRNAs to certain features and risk factors associated with osteoarthritis such as inflammation, obesity, autophagy, and cartilage homeostasis. We also identify certain microRNAs that are differentially expressed in osteoarthritis but have unidentified targets and functions in the disease state. Lastly, we identify the potential use of microRNAs for therapeutic purposes and also mention certain remedies that regulate microRNA expression.
Study Information
pubmed
2016
2016-07-11T00:00:00.000Z
10.1007/s11926-016-0604-x
109
189