Unknown
NA
INTERVENTIONAL
NCT04505059
Different Anesthetic Strategies on Postoperative Cognitive Function and Delirium in Patients Undergoing Cardiac Surgery
View on ClinicalTrials.gov
Updated Dec 15, 2025
Brief Summary
This is a prospective, multi-center, double-blind, randomized clinical trials.
Detailed Description
Prospective randomized multi-center trial involving about 502 subjects will be enrolled in 3 centers. Patients will be randomized to two groups in equal proportion. Investigators set a hypothesis that precision cardiac anesthesia, which involves the modification of several crucial anesthetic modalities, would reduces the incidence of postoperative cognitive function and delirium in patients undergoing cardiac surgery.
Interventions
Name:
Precision cardiac anesthesia
Type:
PROCEDURE
Description:
Aperi-operative anesthetic management through target-controlled infusion to accurately control the patient blood concentration, with combination of bispectral index and neuromuscular monitoring to adjust the dosage of general anesthetics.
Name:
Conventional cardiac anesthesia
Type:
PROCEDURE
Description:
The anesthesia strategy is mainly depending on the anesthesiologist's clinical experience
Primary Outcomes
Measure:
Rate of postoperative delirium
TimeFrame:
Postoperative day 1 to 5
Description:
Delirium assessed by using Confusion Assessment Method-ICU (CAM-ICU) in the postoperative period
Trial Information
NCT ID
NCT04505059
Status
Unknown
Study Type
INTERVENTIONAL
Phases
NA
Sponsor
China National Center for Cardiovascular Diseases
Last Updated
December 15, 2025