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IGF-1

Insulin-like Growth Factor 1, Somatomedin C

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Studies 92
Trials 100
Completed OBSERVATIONAL NCT02535637

Breastfeeding and Obesity on Offspring Body Composition

View on ClinicalTrials.gov Updated Dec 15, 2025

Brief Summary

The purpose of this study is to explore the effect maternal obesity and breastfeeding play on infant body composition. The investigators hypothesize in the first 6 months of life breast fed offspring from overweight / obese mothers will be fatter with greater trunk fat mass and accumulate fat at a greater rate than breast fed infants from normal weight mothers. Furthermore, the investigators postulate that circulating maternal milk adipocytokines will positively correlate to total fat mass at six months of age.

Detailed Description

The objective of this study is to determine if offspring from overweight/obese non-diabetic mothers whom breastfeed have greater total fat and trunk fat mass and accumulate fat mass at a greater rate from \~ 1 month to 6 months of life compared to breastfed infants from normal weight mothers. Specific Aim 1: Understand how maternal obesity and breast-feeding impact body composition of the offspring. Based upon the investigators preliminary data and counter to accepted dogma the hypothesis is at six months of age total fat mass, particularly in the trunk will be elevated at 6 months of age in infants whose mother was either overweight or obese vs. infants from normal weight mothers. Specific Aim 2: Identify adipocytokines in breast milk. The postulate is breast milk from overweight and obese mothers will have greater levels of insulin, glucose, Ghrelin, IGF-1, IL-6, TNFα, high-sensitivity C-reactive protein, and lower Leptin levels than breast milk from normal weight mothers and will be correlated with offspring fat mass.

Interventions

Name: Exclusively breastfeed
Type: OTHER
Description: There is no intervention other than mothers must exclusively breastfeed.

Primary Outcomes

Measure: The association of breast milk adipocytokines with maternal body mass index at one and 6-months of age.
TimeFrame: One to 6-months.
Description: The associations between breast milk adipocytokines and maternal fatness (i.e. body mass index) will be determined at both one and 6-months.
Measure: The association of breast milk adipocytokines with infant body composition at one and 6-months of age.
TimeFrame: One to 6-months.
Description: The associations between breast milk adipocytokines and infant body composition (i.e. total fat and fat-free mass and the percentage of body fat) will be determined at both one and 6-months.

Trial Information

NCT ID

NCT02535637

Status

Completed

Study Type

OBSERVATIONAL

Sponsor

University of Oklahoma

Last Updated

December 15, 2025