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IGF-1

Insulin-like Growth Factor 1, Somatomedin C

Quick Stats
Studies 92
Trials 100
Completed NA INTERVENTIONAL NCT00533065

Effects of Donepezil on Deficits Associated With Age-Related Decrease of Growth Hormone

View on ClinicalTrials.gov Updated Dec 15, 2025

Brief Summary

The planned study has two purposes: 1. It is to provide evidence that the administration of a cholinesterase inhibitor will result in an increase of IGF-I (primary variable) and in an increase of the secretion growth hormone (secondary variable) that can be maintained throughout the treatment-period of one year. 2. The study also tests the hypothesis that maintenance of increased blood levels of growth hormone and IGF-I can stop or delay the age-related changes of body composition (secondary variables) .

Interventions

Name: Donepezil
Type: DRUG
Description: week1 - week12: 1 tablet per day (5mg) week13 - week52: 1 tablet per day (10mg)

Primary Outcomes

Measure: Serum IGF1
TimeFrame: one year
Description:

Trial Information

NCT ID

NCT00533065

Status

Completed

Study Type

INTERVENTIONAL

Phases

NA

Sponsor

Ludwig Boltzmann Gesellschaft

Last Updated

December 15, 2025