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Kisspeptin-10

KP-10, Metastin (45-54), Kisspeptin-10 (human), KiSS-1

Quick Stats
Studies 877
Trials 47
Completed PHASE1 INTERVENTIONAL NCT05971849

Dampening the Reproductive Axis With Continuous Kisspeptin

View on ClinicalTrials.gov Updated Dec 15, 2025

Brief Summary

The goal of this study is to assess response to kisspeptin as well as the baseline patterns of luteinizing hormone (LH) secretion in individuals with polycystic ovarian syndrome (PCOS).

Detailed Description

Assignment: All study subjects will undergo the same interventions. Baseline LH secretion patterns of individuals with PCOS will be compared to their LH secretion patterns while receiving a kisspeptin infusion. Delivery of Interventions: * Prior to the inpatient study visit, the subjects will undergo a review of their medical history, physical exam, and screening laboratories. * On the day of the study, the subjects will have an intravenous (IV) line placed and * Undergo up to q10 min blood sampling x 36 hours * Receive an infusion of kisspeptin x 24 hours * Receive up to two kisspeptin IV boluses

Interventions

Name: kisspeptin 112-121
Type: DRUG
Description: IV infusion of kisspeptin 112-121 x 24 hours; up to two IV boluses of kisspeptin

Primary Outcomes

Measure: Average change in LH pulse frequency
TimeFrame: 6 hours prior to kisspeptin infusion compared to the final 6 hours of kisspeptin infusion
Description: Average change in LH pulse frequency before and during kisspeptin infusion
Measure: Average change in LH pulse amplitude
TimeFrame: 6 hours prior to kisspeptin infusion compared to the final 6 hours of kisspeptin infusion
Description: Average change in LH pulse amplitude before and during kisspeptin infusion

Trial Information

NCT ID

NCT05971849

Status

Completed

Study Type

INTERVENTIONAL

Phases

PHASE1

Sponsor

Stephanie B. Seminara, MD

Last Updated

December 15, 2025