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Kisspeptin-10

KP-10, Metastin (45-54), Kisspeptin-10 (human), KiSS-1

Quick Stats
Studies 877
Trials 47
Completed PHASE1 INTERVENTIONAL NCT01438073

Elucidating Kisspeptin Physiology by Blocking Kisspeptin Signaling

View on ClinicalTrials.gov Updated Dec 15, 2025

Brief Summary

The investigators are looking for subjects to complete a study on the role of kisspeptin in the reproductive system. Kisspeptin is a naturally occurring hormone in humans that tells the body to produce other reproductive hormones. However, giving someone a continued amount of kisspeptin over a period of time can have the opposite effect and tell the body to, for a short time, stop making hormones needed for reproduction. By giving 24-hour infusions of kisspeptin, the investigators hope to learn more about the role kisspeptin has in the way bodies function normally and the role it has in conditions that affect the reproductive system.

Detailed Description

Please contact study staff for a detailed description.

Interventions

Name: kisspeptin 112-121
Type: DRUG
Description: 24-h continuous intravenous infusion of kisspeptin 112-121 (12.5-40 mcg/kg/h), single intravenous dose of kisspeptin 112-121 (0.313-13.19 mcg/kg)
Name: GnRH
Type: DRUG
Description: Single intravenous dose of GnRH (2.5-250 ng/kg)

Primary Outcomes

Measure: Average difference in Luteinizing Hormone (LH) concentration at the beginning and end of kisspeptin infusion
TimeFrame: 24 hours
Description:

Trial Information

NCT ID

NCT01438073

Status

Completed

Study Type

INTERVENTIONAL

Phases

PHASE1

Sponsor

Massachusetts General Hospital

Last Updated

December 15, 2025