Intraperitoneal kisspeptin-10 administration ameliorates sodium arsenite-induced reproductive toxicity in adult male mice.
Fatima. Iffat I; Qureshi. Irfan Zia IZ
Key Findings
- Intraperitoneal kisspeptin-10 (50 nmol/day) reduced oxidative stress and boosted antioxidant enzymes in arsenic‑exposed male mice.
- Kisspeptin‑treated mice had higher serum testosterone, seminal fructose, and improved sperm quality versus arsenic‑only mice.
- Histology showed that kisspeptin prevented germ cell loss and tissue damage in the testes caused by arsenic.
Practical Outcomes
- The study suggests kisspeptin‑10 might protect male reproductive health under toxic stress, but it was done in mice using injections, not oral supplements. There is no human dosing or safety data, so biohackers should view this as early‑stage evidence rather than a ready‑to‑use protocol. If you’re concerned about arsenic exposure, focusing on reducing that exposure is more actionable than trying to use kisspeptin‑10 at this stage.
Summary
In a mouse study, giving the peptide kisspeptin-10 by injection helped protect male reproductive organs from damage caused by arsenic in drinking water. The treated mice showed better antioxidant activity, higher testosterone, healthier sperm, and less tissue damage compared to mice that only got arsenic.
Abstract
The current study investigated the protective ameliorative effect of intraperitoneally administered kisspeptin-10 (50 nmol/day) against reproductive toxicity in adult male mice challenged with 35 days of exposure to sodium arsenite in drinking water. Mice were divided into tap water control, sodium arsenite-alone (4 ppm and 10 ppm), kisspeptin-alone (intermittent and continuous) and combined (sodium arsenite +kisspeptin-10 intermittent and continuous) treatment groups. Results revealed protective effect of both intermittent and continuous kisspeptin doses on reproductive organs against sodium arsenite-induced toxicity. This was indicated by an increase (p < 0.001) in the activity of antioxidant enzymes and a decrease (p < 0.001) in the levels of oxidative stress biomarkers. Concomitant significant increase was noticeable in the relative organ weight (p < 0.01), and serum testosterone and seminal fructose (p < 0.001), and a significant improvement in sperm parameters was also observed. A significant downregulation of lactate dehydrogenase concentration demonstrated further the protective effect of kisspeptin against tissue damage. Histologically, both treatment regimens of kisspeptin combined with sodium arsenite exposure prevented massive germ cell loss and tissue damage, a condition prominent in sodium arsenite-alone-treated mice. The study demonstrates for the first time kisspeptin's potential to mitigate the biochemical and histotoxic effects of arsenic on male reproductive system.
Study Information
pubmed
2021
2021-12-12T00:00:00.000Z
10.1111/and.14347
3
51