Variants in the Kisspeptin-GnRH Pathway Modulate the Hormonal Profile and Reproductive Outcomes.
Martins Trevisan. Camila C; Naslavsky. Michel Satya MS; Monfardini. Frederico F; Wang. Jaqueline J; Zatz. Mayana M; Peluso. Carla C; Pellegrino. Renata R; Mafra. Fernanda F; Hakonarson. Hakon H; Ferreira. Frederico Moraes FM; Nakaya. Helder H; Christofolini. Denise Maria DM; Montagna. Erik E; Crandall. Keith A KA; Barbosa. Caio Parente CP; Bianco. Bianca B
Key Findings
- Certain KISS1 and KISS1R gene variants are linked to changes in LH, AMH, FSH and estradiol levels.
- UTR variants are associated with lower prolactin.",
Practical Outcomes
- For most DIY health enthusiasts, the work is mainly scientific and not a ready‑to‑use protocol. It suggests that personal genetics may affect how your body responds to kisspeptin‑related interventions, so genetic testing could eventually help tailor hormone‑modulating strategies, but more research is needed before practical application.
Summary
This study looked at DNA differences in the kisspeptin and GnRH pathways and found they can change hormone levels and IVF success in women, but it didn’t test kisspeptin‑10 as a supplement or give dosing advice.
Abstract
Kisspeptin has been identified as a key regulatory protein in the release of gonadotropin-releasing hormone (GnRH), which subsequently increases gonadotropin secretion during puberty to establish reproductive function and regulate the hypothalamic-pituitary-gonadal axis. The effects of variants in the <i>KISS1</i>, <i>KISS1R,</i> and <i>GNRHR</i> genes and their possible association with assisted reproduction outcomes remain to be elucidated. In this study, we used next-generation sequencing to investigate the associations of the genetic diversity at the candidate loci for <i>KISS1</i>, <i>KISS1R,</i> and <i>GNRHR</i> with the hormonal profiles and reproductive outcomes in 86 women who underwent <i>in vitro</i> fertilization treatments. Variants in the <i>KISS1</i> and <i>KISS1R</i> genes were associated with luteinizing hormone (rs35431622:T>C), anti-Mullerian hormone (rs71745629delT), follicle-stimulating hormone (rs73507529:C>A), and estradiol (rs73507527:G>A, rs350130:A>G, and rs73507529:C>A) levels, as well as with reproductive outcomes such as the number of oocytes retrieved (s35431622:T>C), metaphasis II oocytes (rs35431622:T>C), and embryos (rs1132506:G>C). Additionally, variants in the <i>GNRHR</i> UTR3' (rs1038426:C>A, rs12508464:A>C, rs13150734:C>A, rs17635850:A>G, rs35683646:G>A, rs35610027:C>G, rs35845954:T>C, rs17635749:C>T, and rs7666201:C>T) were associated with low prolactin levels. A conjoint analysis of clinical, hormonal, and genetic variables using a generalized linear model identified two variants of the <i>KISS1</i> gene (rs71745629delT and rs1132506:G>C) that were significantly associated with hormonal variations and reproductive outcomes. The findings suggest that variants in <i>KISS1, KISS1R</i>, and <i>GNRHR</i> genes can modulate hormone levels and reproductive outcomes.
Study Information
pubmed
2020
2020-04-29T00:00:00.000Z
10.1089/dna.2019.5165
3
67