The role of kisspeptin system in cancer biology.
Stathaki. Martha M; Stamatiou. Maria Evanthia ME; Magioris. George G; Simantiris. Spyridon S; Syrigos. Nikolaos N; Dourakis. Spyridon S; Koutsilieris. Michael M; Armakolas. Athanasios A
Key Findings
- Kisspeptin peptides regulate reproductive hormones and are essential for puberty onset and ovulation.
- Laboratory studies suggest kisspeptin can inhibit cancer cell metastasis in several tumor types.
- Targeting the kisspeptin signaling pathway is being investigated as a potential strategy to improve cancer outcomes.
Practical Outcomes
- At this stage, there are no proven dosing guidelines or safe protocols for self‑administration of kisspeptin‑10. The findings are mainly of interest to researchers developing future cancer therapies, not to biohackers looking for immediate health or performance benefits.
Summary
Kisspeptin-10 is a brain‑derived peptide best known for triggering puberty and ovulation. Scientists have also found that it can slow the spread of some cancers in lab studies, and they are exploring ways to use it as a cancer treatment. However, the research is still early and does not give any clear instructions for personal use.
Abstract
Kisspeptins are a family of neuropeptides that are known to be critical in puberty initiation and ovulation. Apart from that kisspeptin derived peptides (KPs) are also known for their antimetastatic activities in several malignancies. Herein we report recent evidence of the role of kisspeptins in cancer biology and we examine the prospective of targeting the kisspeptin pathways leading to a better prognosis in patients with malignant diseases.
Study Information
pubmed
2019
2019-08-03T00:00:00.000Z
10.1016/j.critrevonc.2019.07.015
19
122