In a rat study, giving kisspeptin‑10 helped boost antioxidant enzymes in the testes and reduced damage caused by a high‑methionine diet, without harming sperm cells. The hormone changes were modest, and the work is only in young rats, not people.

Disruption of the balance oxidants, antioxidants cause various pathophysiological conditions such as lipid peroxidation, protein degradation, or DNA damage. We have examined possible effects of kisspeptin-10 on the structural damage produced by methionine-induced lipid peroxidation in testicle tissue of young rats. Kisspeptin-10 did not significantly affect spermatogenic cells in seminiferous tubules. Testosterone levels decreased in the methionine group as compared with the control group but without statistical significance. Luteinizing hormone levels decreased in the methionine group as compared with the control group (P < 0.001). Catalase enzyme activity increased in the kisspeptin-10 group (P < 0.01) as compared with the other groups. Catalase mRNA expression was decreased in the methionine group as compared with the kisspeptin group (P < 0.001). Total superoxide dismutase enzyme activity and superoxide dismutase mRNA expression were increased in the kisspeptin group as compared with the methionine group (P < 0.05). In conclusion, kisspeptin treatment may protect the structure of spermatogenic cells against methionine-induced damage.