Mutations in KISS1 are not responsible for idiopathic hypogonadotropic hypogonadism in Chinese patients.
Zhang. Yiming Y; Zhang. Haobo H; Qin. Yingying Y; Zhang. Yingchun Y; Chen. Xinxia X; Li. Weiping W; Chen. Zi-Jiang ZJ
Key Findings
- Screened 170 IHH patients and 187 matched controls for KISS1 mutations
- Identified two known SNPs (c.58G>A and c.242C>G) but their frequencies didn’t differ between groups
- Concluded coding mutations in KISS1 are not common in Chinese IHH patients
Practical Outcomes
- For biohackers, this means there’s no evidence to target kisspeptin‑10 based on KISS1 gene mutations for treating this condition, and the paper doesn’t provide new dosing or protocol advice.
Summary
The study checked whether changes in the KISS1 gene cause a hormone deficiency called idiopathic hypogonadotropic hypogonadism in Chinese people and found no link—common gene variants were the same in patients and healthy folks.
Abstract
To investigate whether mutations in the KISS1 gene are present in 170 Chinese patients with idiopathic hypogonadotropic hypogonadism (IHH). Mutational screening of the KISS1 gene was performed in 170 Chinese patients with IHH (133 male cases and 37 female cases) and 187 matched controls (94 males and 93 females). Two known single-nucleotide polymorphisms (SNP), c. 58G > A in exon 1 and c. 242C > G in exon 2, were identified. However, no difference of genotype and allelic frequencies between cases and controls was observed. The results suggest that mutations in the coding sequence of KISS1 are not common in patients with IHH in this Chinese population.
Study Information
pubmed
2015
2015-01-27T00:00:00.000Z
10.1007/s10815-014-0424-8
2
31