Circulating levels of leptin, nesfatin-1 and kisspeptin in postmenopausal obese women.
Çelik. Feyza F; Belviranli. Muaz M; Okudan. Nilsel N
Key Findings
- Leptin levels were significantly higher in obese women compared to non‑obese women.
- Nesfatin-1 levels did not differ between any of the groups (obese vs. non‑obese, pre‑ vs. post‑menopausal).
- Kisspeptin-10 levels were unchanged across obesity status and menopausal status.
Practical Outcomes
- For biohackers, this study suggests that simply changing body weight or menopausal status is unlikely to affect circulating kisspeptin-10 levels, so there’s no direct protocol to tweak kisspeptin for weight or reproductive benefits based on this data. It mainly confirms existing knowledge that kisspeptin isn’t a useful biomarker for obesity or menopause in women.
Summary
In a study of 83 women, researchers found that while obese women had higher leptin levels, the amounts of the hormones nesfatin-1 and kisspeptin (including kisspeptin-10) in the blood were the same regardless of whether the women were obese or not, and whether they were pre‑ or post‑menopausal.
Abstract
The roles of leptin, nesfatin-1 and kisspeptin in the regulation of food intake and/or reproduction are well known; however, the interactions between these hormones remain unclear, especially in humans. The aim of this study was to determine the roles of leptin, nesfatin-1 and kisspeptin in pre- and postmenopausal obese and non-obese women. The study included 83 women who were divided into four groups based on menopausal status and body mass index. The leptin level was significantly higher in the obese women than in the non-obese women (p < 0.05), but did not differ significantly between pre- and postmenopausal women (p > 0.05). The nesfatin-1 and kisspeptin-1 levels did not differ significantly between any of the study groups (p > 0.05). The present findings show that nesfatin-1 and kisspeptin levels are not affected by obesity or menopausal status.
Study Information
pubmed
2016
2016-04-20T00:00:00.000Z
10.3109/13813455.2016.1171365
26
40