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Kisspeptin-10

KP-10, Metastin (45-54), Kisspeptin-10 (human), KiSS-1

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Studies 877
Trials 47
Overview Studies Clinical Trials
Score 1
2016 pubmed

Pubertal development and regulation.

Abreu. Ana Paula AP; Kaiser. Ursula B UB

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Key Findings

  • Puberty is driven by the hypothalamic‑pituitary‑gonadal axis, which is tightly regulated by many excitatory and inhibitory signals.
  • The re‑activation of this axis at puberty is not fully understood; genetics, metabolism, and other factors play roles.
  • Variations in the age of puberty onset are linked to long‑term health outcomes in adulthood.

Practical Outcomes

  • For biohackers, the review offers background knowledge but no direct, actionable protocols for using kisspeptin‑10. It highlights that manipulating puberty timing is complex and currently lacks clear, safe methods for self‑experimentation.

Summary

The paper reviews how puberty starts and is controlled by the brain‑pituitary‑gonadal hormone system. It explains that this system is active early in life, then paused during childhood, and re‑starts at puberty, but the exact triggers are still unclear. Timing of puberty can affect health later in life.

Abstract

Puberty marks the end of childhood and is a period when individuals undergo physiological and psychological changes to achieve sexual maturation and fertility. The hypothalamic-pituitary-gonadal axis controls puberty and reproduction and is tightly regulated by a complex network of excitatory and inhibitory factors. This axis is active in the embryonic and early postnatal stages of life and is subsequently restrained during childhood, and its reactivation culminates in puberty initiation. The mechanisms underlying this reactivation are not completely known. The age of puberty onset varies between individuals and the timing of puberty initiation is associated with several health outcomes in adult life. In this Series paper, we discuss pubertal markers, epidemiological trends of puberty initiation over time, and the mechanisms whereby genetic, metabolic, and other factors control secretion of gonadotropin-releasing hormone to determine initiation of puberty.

Study Information

Provider

pubmed

Year

2016

Date

2016-02-04T00:00:00.000Z

DOI

10.1016/s2213-8587(15)00418-0