Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men.
George. J T JT; Veldhuis. J D JD; Roseweir. A K AK; Newton. C L CL; Faccenda. E E; Millar. R P RP; Anderson. R A RA
Key Findings
- IV bolus of kisspeptin‑10 causes a rapid, dose‑dependent rise in LH, peaking at 1 µg/kg
- A higher bolus (3 µg/kg) produces a smaller LH response than the 1 µg/kg dose
- Continuous infusion (1.5 µg/kg·h) increases mean LH, testosterone, LH pulse frequency, and burst mass
Practical Outcomes
- For biohackers, kisspeptin‑10 could serve as a fast‑acting way to stimulate the body’s own testosterone production. The most effective single‑shot dose appears to be ~1 µg/kg IV, but delivering the peptide continuously (e.g., via infusion) is less practical outside a lab. More safety data are needed before routine self‑administration, but the peptide shows promise for short‑term testosterone boosting protocols.
Summary
Kisspeptin-10 is a tiny peptide that, when injected into men, quickly spikes the hormone LH, which in turn lifts testosterone levels. A single IV dose of about 1 µg per kg gives the strongest LH boost, while higher doses actually blunt the effect. Keeping a low‑dose infusion going for many hours further raises testosterone and makes LH pulses come more often and bigger.
Abstract
Kisspeptins stimulate GnRH and thus gonadotropin secretion. Kisspeptin-10 is the minimal kisspeptin sequence with full intrinsic bioactivity, but it has not been studied in man. We investigated our hypothesis that kisspeptin-10 increases GnRH and thus LH pulse frequency. The dose response of kisspeptin-10 was investigated by administering iv bolus doses (0.01-3.0 μg/kg) and vehicle to healthy men. Effects on LH pulse frequency and size were determined by deconvolution analysis during infusion of kisspeptin-10 for up to 22.5 h. Intravenous bolus kisspeptin-10 resulted in a rapid and dose-dependent rise in serum LH concentration, with maximal stimulation at 1 μg/kg (4.1 ± 0.4 to 12.4 ± 1.7 IU/liter at 30 min, P < 0.001, n = 6). Administration of 3 μg/kg elicited a reduced response vs. 1 μg/kg (P < 0.05). Infusion of kisspeptin-10 at 4 μg/kg · h for 22.5 h elicited an increase in LH from a mean of 5.4 ± 0.7 to 20.8 ± 4.9 IU/liter (n = 4; P < 0.05) and serum testosterone increased from 16.6 ± 2.4 to 24.0 ± 2.5 nmol/liter (P < 0.001). LH pulses were obscured at this high rate of secretion, but a lower dose infusion of kisspeptin-10 (1.5 μg/kg · h) increased mean LH from 5.2 ± 0.8 to 14.1 ± 1.7 IU/liter (n = 4; P < 0.01) and increased LH pulse frequency from 0.7 ± 0.1 to 1.0 ± 0.2 pulses/h (P < 0.05) and secretory burst mass from 3.9 ± 0.4 to 12.8 ± 2.6 IU/liter (P < 0.05). Kisspeptin-10 boluses potently evoke LH secretion in men, and continuous infusion increases testosterone, LH pulse frequency, and pulse size. Kisspeptin analogues have therapeutic potential as regulators of LH and thus testosterone secretion.
Study Information
pubmed
2011
2011-06-01T00:00:00.000Z
10.1210/jc.2011-0089
168
44