Effect of Peripheral Administration of Kisspeptin-10 on Dynamic LH Secretion in Prepubertal Ewes.
Wang. Jun J; Sun. Lei L; Zhang. Tao T; Zhou. Haizhu H; Lou. Yujie Y
Key Findings
- Single intravenous doses of 0.5‑2 mg kisspeptin‑10 significantly increased LH secretion in prepubertal ewes
- Higher doses (1 mg and 2 mg) produced a larger LH response than the lower 0.5 mg dose
- Repeated intravenous dosing (three doses one hour apart) also boosted LH without reducing the peptide’s effect
Practical Outcomes
- For the biohacker community this research offers little direct actionability because it’s an animal study on reproductive hormones, not a human protocol. There’s no guidance on safe or effective dosing in people, and the relevance to longevity, metabolism, or performance is unclear. More human‑focused research would be needed before any practical use.
Summary
Scientists gave a peptide called kisspeptin‑10 to young female sheep and saw that it caused a rapid rise in the reproductive hormone LH, both after a single shot and after several shots given one hour apart. The effect was bigger with higher doses, but the study was done only in pre‑pubertal ewes, not humans.
Abstract
The aim of the present study was to clarify the effect of kisspeptin-10 on LH secretion in prepubertal ewes. In experiment 1, prepubertal ewes fitted with indwelling jugular catheters were randomly assigned to receive 0, 0.5, 1 or 2 mg of kisspeptin-10 dissolved in saline, and serial blood samples were collected at 15-min intervals for 180 min to analyze the response curves of LH after injection. In experiment 2, prepubertal ewes fitted with indwelling jugular catheters were injected with 0 or 1 mg of kisspeptin-10 dissolved in saline and the injection was repeated 3 times at 1 h interval and serial blood samples were collected at 15-min intervals for 210 min to analyze the response curves of LH after injection. The results showed that single intravenous administration of 0.5, 1 and 2 mg of kisspeptin-10 all could significantly increased LH secretion in prepubertal ewes, and the effect of 1 and 2 mg of kisspeptin-10 on LH secretion was higher than that of 0.5 mg group. The results also showed that repeated intravenous administration of kisspeptin-10 could effectively increase LH secretion and repeated administration did not influence the effect of kisspeptin-10 on LH secretion in prepubertal ewe. In conclusion, the present study indicated that single or repeated intravenous administration of kisspeptin-10 could effectively increase LH secretion in prepubertal ewes.
Study Information
pubmed
2012
2012-06-01T00:00:00.000Z
10.5713/ajas.2011.11390
13
16