The study found that pregnant women who experienced early bleeding had lower levels of the hormone kisspeptin‑10 compared to those without bleeding, and lower kisspeptin‑10 was linked to later pregnancy complications, but the research is very small and doesn’t show how to use this information outside of a clinical setting.

To investigate the association between kisspeptin 10 (Kp-10) levels and early pregnancy bleeding and perinatal outcome. A total of 20 pregnant women with the complaint of vaginal bleeding during 7-18 gestational weeks and 20 healthy gestational week matched pregnant women were included in the study. Maternal plasma Kp-10 levels were measured with the enzyme immunoassay method. Adverse pregnancy outcomes like intrauterine growth restriction, preterm delivery, preeclampsia and low birth weight were evaluated in both groups. Maternal plasma Kp-10 levels (p = 0.01) and birth weight (p = 0.06) were found to be lower in women with bleeding. Intrauterine growth restriction, preterm delivery and intrauterine exitus were noted more commonly in women with bleeding (10 vs. 0%, 25 vs. 15% and 20 vs. 0%, p = 0.08). Preeclampsia were developed in 5% of both groups. Kp-10 levels showed positive correlation with gestational week (p = 0.02) and ALT levels (p = 0.02). [corrected] Kp-10 levels were found lower in women with early pregnancy bleeding.