Centrally injected kisspeptin reduces food intake by increasing meal intervals in mice.
Stengel. Andreas A; Wang. Lixin L; Goebel-Stengel. Miriam M; Taché. Yvette Y
Key Findings
- Central (ICV) kisspeptin-10 sharply reduces food intake in fast‑ed mice in a dose‑dependent way
- The 1 µg dose cuts 4‑hour cumulative intake by about 28%
- The lower intake is due to fewer meals, not smaller meals, and peripheral injection has no effect
Practical Outcomes
- For biohackers, kisspeptin isn’t ready for use because it must act in the brain, and standard injections don’t work in mice. It points to a possible target for appetite control, but no safe, practical dosing protocol exists yet.
Summary
Injecting kisspeptin-10 directly into the brain of mice makes them eat less by spacing out meals, but giving it by a regular injection under the skin does nothing. The effect works best at a specific dose and lasts a few hours after a fast.
Abstract
Kisspeptin is distributed not only in brain areas for regulating reproduction but also in nuclei involved in feeding control. Whether kisspeptin alters food intake is unknown in mice. We examined how kisspeptin-10 influences feeding after intracerebroventricular injection in mice using automated monitoring. Kisspeptin-10 (0.3, 1, and 3 μg/mouse) dose-dependently inhibited the feeding response to an overnight fast by 50, 95, and 90% respectively, during the 2-3 h period postinjection. The 1μg/mouse dose reduced the 4-h cumulative food intake by 28% whereas intraperitoneal injection (10 μg/mouse) did not. The decreased 4-h food intake was due to reduced meal frequency (-45%/4 h), whereas meal size and gastric emptying were not altered. These data suggest that kisspeptin may be a negative central regulator of feeding by increasing satiety.
Study Information
pubmed
2011
2011-03-30T00:00:00.000Z
10.1097/wnr.0b013e32834558df