[Relationship among the expression of lymphatic vessel density, microvessel density, carcinoembryonic antigenic mRNA, KAI1, and Kiss-1, and prognosis in patients with non-small cell lung cancer].
Wang. Guowen G; Wang. Zuyi Z; Li. Chuankui C; Wang. Ping P; Chai. Damin D; Cheng. Zenong Z
Key Findings
- Higher Kiss-1 expression is associated with better survival in NSCLC patients but isn’t an independent prognostic factor
- CEA mRNA levels are an independent predictor of survival
- Microvessel density, lymphatic vessel density, and Kiss-1 levels correlate with prognosis but are less predictive than tumor stage and lymph node spread
Practical Outcomes
- For biohackers, this research doesn’t provide a direct way to use kisspeptin-10 for health or performance. It mainly shows that Kiss-1 is linked to cancer outcomes, so any supplementation would be speculative and potentially risky.
Summary
The study looked at lung cancer patients and found that higher levels of certain markers, including the protein Kiss-1, were linked to how long patients survived, but Kiss-1 itself wasn’t a strong independent predictor of outcome.
Abstract
In recent years, many studies have revealed the prognosis in patients with non-small cell lung cancer (NSCLC). In general, some clinic-pathological parameters have been related with prognosis. The aim of this study is to detect the relationship among lymphatic vessel density (LVD), microvessel density (MVD), expression of carcinoembryonic antigen (CEA) mRNA, metastasis suppressor genes (KAI1 and Kiss-1), and the prognosis of NSCLC patients. Blood samples were collected from 57 cases of NSCLC. The transcription of CEA mRNA was detected via nested reverse transcriptase-polymerase chain reaction and micro-fluid chip. Immunohistochemistry was performed to detect the expression of LVD, MVD, KAI1 and Kiss-1 in the patients. All follow-up data were collected and analyzed. The overall five-year survival rate was 18%, and the median survival was 34 months. TNM stage, lymph node metastasis, and expression of MVD, LVD, CEA mRNA and Kiss-1 were factors to survival, as determined via single survival analysis. Multivariate analysis demonstrated that TNM stage, lymph node metastasis, and expression of CEA mRNA were independent prognostic factors for NSCLC patients. The expression of MVD, LVD, Kiss-1 and CEA mRNA is related to the prognosis of NSCLC.
Study Information
pubmed
2012
2012-06-20T00:00:00.000Z
10.3779/j.issn.1009-3419.2012.06.05
4
20