Kisspeptin and fertility.
Hameed. Saira S; Jayasena. Channa N CN; Dhillo. Waljit S WS
Key Findings
- Kisspeptin and its receptor are central to turning on the hypothalamic‑pituitary‑gonadal (HPG) axis.
- The peptide drives the release of gonadotropins (LH and FSH) and influences sex steroid production.
- Researchers are exploring kisspeptin as a possible therapy for infertility and other reproductive disorders.
Practical Outcomes
- For now, the information is mainly scientific background; there are no proven dosing guidelines or ready‑to‑use protocols for self‑administration. It suggests that future treatments might target kisspeptin to boost fertility, but enthusiasts should wait for clinical trials before trying it themselves.
Summary
Kisspeptin is a small protein that tells the brain to release hormones that control the ovaries and testes. This review explains how kisspeptin helps start and regulate the hormone cascade needed for fertility, and it looks at whether giving kisspeptin could treat reproductive problems.
Abstract
The kisspeptins are a family of peptide hormones, which in recent years have been shown to play a critical role in the regulation of the hypothalamic-pituitary-gonadal axis, thus in turn influencing fertility and reproduction. This review examines the physiological role of kisspeptin and the kisspeptin receptor in the control of gonadotrophin and gonadal steroid hormone secretion and the implications of these findings with respect to fertility. In addition, the potential therapeutic use of kisspeptin in the treatment of reproductive disorders will be examined.
Study Information
pubmed
2010
2010-11-17T00:00:00.000Z
10.1677/joe-10-0265