Peripheral administration of kisspeptin-10 increases plasma concentrations of GH as well as LH in prepubertal Holstein heifers.
Kadokawa. H H; Matsui. M M; Hayashi. K K; Matsunaga. N N; Kawashima. C C; Shimizu. T T; Kida. K K; Miyamoto. A A
Key Findings
- A single 1 mg IV dose of kisspeptin‑10 raised LH, peaking about 27 ± 3 minutes after injection.
- The same dose raised GH, peaking about 75 ± 9 minutes after injection.
- No hormone spikes were seen in the saline‑treated control cows, indicating the effect is specific to kisspeptin‑10.
Practical Outcomes
- The result hints that kisspeptin could simultaneously boost growth‑related and reproductive hormones, but because it’s animal data, there’s no safe or effective human dosing protocol yet. Biohackers should treat this as a mechanistic clue rather than a ready‑to‑use supplement strategy and await human studies.
Summary
Injecting kisspeptin-10 into young dairy cows caused short‑term spikes in both growth hormone (GH) and luteinizing hormone (LH), showing the peptide can affect the body’s growth and reproductive systems, but the study was done in pre‑pubertal cattle, not humans.
Abstract
This study was conducted to estimate the effects of kisspeptin-10 on blood concentrations of LH and GH in prepubertal dairy heifers. Heifers received a single injection of 1 mg kisspeptin-10 (n=5) or saline (n=5) intravenously, and serial blood samples were collected at 15-min intervals to analyze the response curves of both LH and GH after injection. Peak-shaped responses were observed for concentrations of LH and GH, and the peaks were observed at 27+/-3 and 75+/-9 min, respectively, after injection, only in heifers injected with kisspeptin-10. These data suggest various possible important links among kisspeptin, the reproductive axis, and also the somatotropic axis in prepubertal Holstein heifers.
Study Information
pubmed
2008
10.1677/joe-07-0504