From KISS1 to kisspeptins: An historical perspective and suggested nomenclature.
Gottsch. Michelle L ML; Clifton. Donald K DK; Steiner. Robert A RA
Key Findings
- KISS1 was first identified as a cancer‑suppressing gene that blocks metastasis
- KISS1 and its receptor KISS1R are essential regulators of puberty onset across species
- Recent research connects the kisspeptin system to vasoconstriction, aging processes, adipocyte biology, and possibly linking metabolism with reproductive function
Practical Outcomes
- While the review doesn’t give dosing or protocol advice, it highlights kisspeptin pathways as potential targets for future anti‑aging or metabolic interventions, so biohackers should watch for emerging studies that test kisspeptin‑based therapies.
Summary
This paper reviews the history of the KISS1 gene and its protein products, called kisspeptins, showing they were first known for stopping cancer spread, then discovered to control puberty and have ties to blood vessel tone, aging, fat cell function, and the link between metabolism and reproduction. It also suggests a standard naming system for these molecules.
Abstract
The cancer suppressor gene, KISS1, was initially described as having an important role in inhibiting cancer metastasis. Since then, KISS1 and its receptor, KISS1R, have been shown to play a key role in controlling the onset of puberty of reproductive physiology in the human and other species. Recent studies have also linked KISS1/kisspeptin/KISS1R to other processes, such as vasoconstriction, aging, adipocyte physiology, and perhaps as a molecular conduit linking metabolism and reproduction. This article highlights the history of KISS1/kisspeptin/KISS1R biology and proposes a consensus for nomenclature of the key molecules in this signaling pathway.
Study Information
pubmed
2008
2008-07-03T00:00:00.000Z
10.1016/j.peptides.2008.06.016
119
63