Regulation of KiSS1 gene expression.
Li. Dali D; Yu. Weishi W; Liu. Mingyao M
Key Findings
- KiSS1 is expressed in both brain and peripheral tissues
- Kisspeptin acts as a puberty gatekeeper and tumor metastasis suppressor
- The exact molecular mechanisms controlling KiSS1 transcription are still being uncovered
Practical Outcomes
- For most DIY health enthusiasts there’s no direct protocol to follow. It mainly tells you that kisspeptin has important roles in puberty and cancer, but current knowledge doesn’t give clear dosing or usage guidelines.
Summary
This paper reviews how the KiSS1 gene, which makes kisspeptin proteins, is controlled in the body. Kisspeptin helps start puberty and can stop cancer spread, but we still don’t fully know what turns the gene on or off.
Abstract
Kisspeptins are the protein products encoded by KiSS1 gene, an important tumor metastatic suppressor and pivotal master hormone of puberty. Although KiSS1 gene is expressed in both central and peripheral tissues, the molecular mechanisms that determine the temporal and spatial expression of KiSS1 gene are not well understood. This review provides an update on the latest studies and ideas about the expression of KiSS1 gene as a puberty gatekeeper and a metastasis suppressor, with special emphasis on the molecular mechanisms for the transcriptional regulation of KiSS1 gene expression.
Study Information
pubmed
2008
2008-10-17T00:00:00.000Z
10.1016/j.peptides.2008.09.025
24
105