Chromosome localization and genomic structure of the KiSS-1 metastasis suppressor gene (KISS1).
West. A A; Vojta. P J PJ; Welch. D R DR; Weissman. B E BE
Key Findings
- KISS1 is located on chromosome 1q32
- The gene has four exons, with the first two not coding for protein
- The coding region starts in exon 3 and continues through exon 4
Practical Outcomes
- For biohackers, the paper offers no direct actions or protocols. It’s mainly a basic genetics reference that may become useful only if future research links KISS1 mutations to disease risk or therapy.
Summary
This study just maps where the KISS1 gene sits in our DNA and shows its basic layout, but it doesn’t give any tips on how to use kisspeptin-10 for health or performance.
Abstract
The identification and sequence of KiSS-1 (HGMW-approved symbol, KISS1), a human malignant melanoma metastasis-suppressor gene, was recently published. In this report, we present a corrected genomic sequence, genomic structure, and refined chromosomal location for KiSS-1. The genomic organization of the sequence reveals a gene consisting of four exons. The first two exons are not translated; the third exon contains 38 5' noncoding bases followed by the translational start site and another 100 translated bases. The terminal exon contains a further 332 translated bases, the translational stop codon, and the polyadenylation signal. The gene maps to chromosome 1q32 as determined by radiation hybrid mapping and FISH analysis. The relatively simple organization of this gene will facilitate analyses for mutations and abnormal expression in human tumors.
Study Information
pubmed
1998
1998-11-15T00:00:00.000Z
10.1006/geno.1998.5566