KISS1 and KISS1R expression in primary and metastatic colorectal cancer.
Matthaiou. Spyridon S; Kostakis. Ioannis D ID; Kykalos. Stylianos S; Machairas. Nikolaos N; Spartalis. Eleftherios E; Ntikoudi. Evangelia E; Lambropoulou. Maria M; Karayiannakis. Anastasios A; Machairas. Nikolaos N
Key Findings
- KISS1 levels are higher in primary colon cancers that are stage III‑IV or have lymph‑node involvement
- KISS1R levels are higher in primary tumors that have spread to distant sites
- Patients with high KISS1R expression in their tumors have longer overall survival
Practical Outcomes
- For biohackers, this work mainly points to kisspeptin as a potential cancer‑related biomarker, not a supplement or protocol you can use. It suggests the KISS1/KISS1R pathway might be worth watching for future therapies, but there’s no actionable dosing or lifestyle advice from this study.
Summary
The study looked at the levels of kisspeptin (KISS1) and its receptor (KISS1R) in colon cancer tissue and found that higher levels show up in more advanced tumors, and surprisingly, people with more KISS1R lived longer. However, the research only measured these proteins in tumor samples and didn’t test any treatments or supplements, so there’s nothing you can directly apply right now.
Abstract
Kisspeptins are produced by the KISS1 gene and have tumor-suppressing and anti-metastatic properties. Our aim was to study the expression of KISS1 and its receptor, KISS1R, in colorectal cancer. KISS1 and KISS1R expression was detected using immunohistochemistry in malignant tissue samples from 66 patients (34 men, 32 women) with colorectal adenocarcinoma. In total, 74 tumor samples were studied, 57 samples from primary tumors and 17 samples from liver metastases. KISS1 and KISS1R levels were associated with various clinicopathological parameters and survival data. KISS1 expression was higher in primary tumors with advanced stage (III or IV) and in those with infiltrated lymph nodes. KISS1R expression was higher in primary tumors with distant metastases. No significant differences were detected between primary and metastatic tumors regarding KISS1 and KISS1R levels. Furthermore, patients with high KISS1R levels had longer overall survival. KISS1 and KISS1R expression is higher in advanced colorectal cancers and high KISS1R levels are associated with better prognosis in colorectal cancer.
Study Information
pubmed
2018