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Kisspeptin-10

KP-10, Metastin (45-54), Kisspeptin-10 (human), KiSS-1

Quick Stats
Studies 877
Trials 47
Overview Studies Clinical Trials
Score 1
2016 pubmed

[Expressions of MACC1, Snail, and KISS-1 Proteins in Infiltrating Breast Carcinoma and Its Clinicopathological Features].

Dong. Hui-Ming HM; Huang. Jian-Kang JK; Gong. Xiao-Meng XM; Tao. Yi-Sheng YS

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Key Findings

  • KISS‑1 protein is much less common in breast cancer tissue than in normal breast tissue
  • Higher KISS‑1 levels in tumors are linked to longer patient survival
  • Higher MACC1 or Snail levels in tumors are linked to shorter patient survival

Practical Outcomes

  • For biohackers, this research doesn’t provide a direct way to use kisspeptin‑10 for health or longevity. It simply suggests that KISS‑1 may act as a natural brake on cancer growth, but no dosing or supplementation guidance can be drawn from these findings.

Summary

The study measured three proteins—MACC1, Snail and KISS‑1—in breast cancer tissue and normal breast tissue. It found that cancer tissue had higher MACC1 and Snail (both linked to worse outcomes) and lower KISS‑1 (a protein that seems to protect against cancer). Patients whose tumors kept KISS‑1 levels high lived longer, while those with high MACC1 or Snail lived shorter lives.

Abstract

To investigate the protein expressions of metastasis-associated in colon cancer 1 (MACC1), KISS-1 (a cancer ruppressor gene) and Snail (the marker of epithelial-mesenchymal transition) in infiltrating breast carcinoma (IBC) and explore the role of them in invasion, metastasis and prognosis in IBC. Expressions of MACC1, Snail and KISS-1 were examined by immunohistochemistry in 250 specimens of IBC and 80 specimens of normal breast tissues. Their clinicopathological features were analyzed, and their influence on patients' survival was identified. The positive rate of MACC1, Snail and KISS-1 in normal breast tissues and IBC tissues was 7.5%, 5.0%, 87.5% and 63.6%, 58.8%, 38.0%, respectively. And there was a significant difference between the IBC group and control group ( <i>P</i>&lt;0.05). The positive expressions of MACC1, Snail and KISS-1 were significantly different in different TNM stages, lymph node metastasis, types and grades of tumor ( <i>P</i>&lt;0.05). The survival time of positive KISS-1 group was significantly longer than that of negative group ( <i>P</i>&lt;0.001); the survival time was significantly shorter in positive MACC1 group or Snail group than that of negative groups (both <i>P</i>&lt;0.001). Cox regression analysis indicated that the positive expressions of MACC1, Snail and negative expression of KISS-1 were independent risk factors of IBC (<i>P</i>&lt;0.05). Abnormal expression of MACC1, Snail and KISS-1 should be involved in the invasion and metastasis of IBC. The combined detection in the expressions of MACC1, Snail and KISS-1 at the early stage may play an important role in predicting the progression and prognosis of IBC.

Study Information

Provider

pubmed

Year

2016