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Kisspeptin-10

KP-10, Metastin (45-54), Kisspeptin-10 (human), KiSS-1

Quick Stats
Studies 877
Trials 47
Overview Studies Clinical Trials
Score 1
2007 pubmed

[Expression of vascular endothelial growth factor and metastin in colorectal carcinoma].

Liang. Qi-Lian QL; Chen. Xiao-Dong XD; Wang. San-Ming SM; Li. Jian-Wen JW; Huang. Bing B; Xu. Yan-Yun YY; Chen. Xue-Song XS

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Key Findings

  • VEGF was over‑expressed in about half of colorectal cancer samples but not in normal tissue
  • Metastin (kisspeptin) was under‑expressed in tumors and higher in normal tissue
  • Higher VEGF and lower metastin levels were associated with worse tumor grade, deeper invasion, higher stage, and lymph node spread

Practical Outcomes

  • For most health‑optimizers this research isn’t directly actionable; it mainly informs cancer diagnostics rather than everyday longevity or performance protocols. It suggests that VEGF and kisspeptin could be useful markers for assessing colon cancer severity, but there’s no immediate implication for supplementation or lifestyle changes.

Summary

The study looked at two proteins, VEGF and metastin (kisspeptin), in colon cancer tissue versus nearby normal tissue. VEGF was higher in tumors, while metastin was lower, and both levels were linked to how aggressive the cancer was.

Abstract

To study the expression of vascular endothelial growth factor (VEGF) and metastin in colorectal carcinoma and their association with the clinicopathological features of the malignancy. VEGF and metastin expressions were examined immunohistochemically with SP method in 70 specimens of human colorectal carcinoma tissues and adjacent normal tissues. VEGF protein overexpression was detected in 48.6% (34/70)of the colorectal carcinoma tissues but in none of the adjacent normal tissues (P<0.01), and for metastin, the overexpression rate was 28.6% (20/70) in the colorectal carcinoma tissues and 70.0% (49/70) in the normal tissues (P<0.01). The expression of both VEGF and metastin was related to the histological grades, infiltration depth, TNM stage and lymph node metastasis of the tumor (P<0.01 and P<0.05, respectively). Immunohistochemical detection of VEGF and metastin can be of value in assessment of the malignancy and in prognostic evaluation of colorectal carcinoma.

Study Information

Provider

pubmed

Year

2007