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Kisspeptin-10

KP-10, Metastin (45-54), Kisspeptin-10 (human), KiSS-1

Quick Stats
Studies 877
Trials 47
Score 2
2009 pubmed

Kisspeptin offers a novel therapeutic target in reproduction.

Jayasena. Channa N CN; Dhillo. Waljit S WS

Key Findings

  • Kisspeptin is a critical regulator of the hypothalamic‑pituitary‑gonadal axis and GnRH release
  • It is seen as a more targeted alternative to older fertility drugs that affect many brain pathways
  • Current research is still at the review stage, with no concrete clinical protocols or dosage guidelines published

Practical Outcomes

  • At this point, the main takeaway for biohackers is that kisspeptin‑based therapies may appear in the future for fertility support, but there are no actionable dosing or self‑experiment protocols to follow now. Keep an eye on emerging clinical trials for any practical applications.

Summary

This review says that the peptide kisspeptin-10 plays a key role in telling the brain to release hormones that control reproduction, and scientists think it could become a new drug for infertility, especially as people try to have kids later in life. However, the paper is a broad overview and doesn’t give any specific dosing or how to use it yourself yet.

Abstract

The occurrence of reproductive infertility has become an increasing concern in the developed world, particularly following the recent trend of attempts at pregnancy later in maternal life. Most existing therapies for infertility, such as clomiphene and gonadotropins, aim to manipulate the traditional components of the hypothalamic-pituitary-gonadal axis. Several secretagogues of gonadotropin-releasing hormone (GnRH) have been identified, including glutamate, neuropeptide tyrosine (NPY) and substance P; however, the broad array of action of these secretagogues in the CNS make them unsuitable as therapeutic targets. In the last 5 years, the Kisspeptin system has emerged as a critical regulator of reproduction and as a putative novel target of therapy for reproductive disorders. This review summarizes the relevant contemporary literature related to Kisspeptin, and assesses the potential applications of this group of peptides as a novel therapeutic target.

Study Information

Provider

pubmed

Year

2009