The study looked at two genes, KISS-1 and its receptor GPR54, in uterine cancer tissue. It found that the cancer samples had less KISS-1 activity than non‑cancer tissue, and lower KISS‑1 was linked to more advanced disease, while GPR54 levels didn’t change much. This suggests KISS‑1 might help keep the cancer from spreading, but the research doesn’t tell us how to use this information for health or performance improvement.

To investigate the expression and clinical significance of KISS-1 mRNA and GPR54 mRNA in endometrial carcinoma. The expression of KISS-1 mRNA and GPR54 mRNA in 32 patients with endometrial carcinoma, 10 patients with endometrial intraepithelial neoplasia (EIN) and 12 patients with normal endometrium was detected by reverse transcriptase polymerase chain reaction (RT-PCR). The positive rate of KISS-1 mRNA in endometrial carcinoma, EIN and normal endometrium was 37.5%, 80.0% and 83.3% respectively (endometrial carcinoma vs EIN or normal endometrium, P < 0.05). The expression of KISS-1mRNA in patients with endometrial carcinoma was correlated with its clinical stage, myometrial invasion and lymph node metastasis (P < 0.05). In endometrial carcinoma, the more advanced clinical stage, the lower expression of KISS-1 mRNA was detected. The positive rate of GPR54 mRNA in endometrial carcinoma, EIN and normal endometrium was 78.1%, 70.0% and 66.7% respectively, with no significant statistical difference (P > 0.05). It was not correlated with the clinical stage, histology grade, myometrial invasion or lymph node metastasis (P > 0.05). The interaction of KISS-1 and GPR54 may play an important role in inhibiting the invasion and metastasis of endometrial carcinoma.