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KPV

Lys-Pro-Val, α-MSH (11-13)

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Studies 104
Trials 57
Overview Studies Clinical Trials
1983 pubmed 9 citations

Comparative studies on duck viral enteritis (DVE) virus strains in geese.

Kisary. J J; Zsak. L L

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Key Findings

  • A vaccine using an avirulent strain fully protects geese against the KPV strain but only partially against the KLM strain.
  • Virulent strains form small, sharp plaques in cell culture, while the avirulent strain forms large, irregular plaques.
  • All three strains are antigenically identical and have similar sensitivity to heat and phosphonoacetic acid, with KLM slightly more resistant to trypsin.

Practical Outcomes

  • For the biohacker community, this research offers no actionable insights for human health, longevity, or performance. It is a veterinary virology study with no direct relevance to human protocols or supplementation.

Summary

The study compares three strains of duck viral enteritis virus in geese, looking at how well a vaccine protects against them and how the viruses behave in cell cultures. It finds that an avirulent strain can protect against one virulent strain but not fully against another, and that all strains are antigenically identical.

Abstract

DVE virus strains isolated from ducks (KPV strain), geese (KLM strain) and an attenuated strain designated DP were compared. Geese vaccinated with the avirulent strain showed 100% protection against the KPV strain, but no or only partial protection against strain KLM, depending on age and sex. Protection against the KLM strain was achieved by using a vaccine containing an avirulent strain and a strain of medium virulence. In goose embryo fibroblast (GEF) cell cultures the virulent strains caused small plaques with sharp margins, whereas the avirulent strain produced large plaques of uneven outline. In the cross-neutralisation tests all strains studied proved to be antigenically identical. The three strains showed similar sensitivity to heat-treatment (at 50 degrees C) and phosphonoacetic acid (PAA), while the KLM strain was slightly more resistant to trypsin-treatment.

Study Information

Provider

pubmed

Year

1983

Date

1983-10-01T00:00:00.000Z

DOI

10.1080/03079458308436185

Citations

9

References

6