A Phase 1 Study of Oral Vitamin D<sub>3</sub> in Boys and Young Men With X-Linked Adrenoleukodystrophy.
Van Haren. Keith P KP; Cunanan. Kristen K; Awani. Avni A; Gu. Meng M; Peña. Dalia D; Chromik. L...
This study tested two ways of giving vitamin D pills to boys and young men with a rare genetic disease (X‑linked adrenoleukodystrophy) that can cause brain damage. Both fixed‑dose and weight‑adjusted dosing raised blood vitamin D to the desired range, and the weight‑adjusted method caused fewer lab‑test warnings. Brain antioxidant (glutathione) levels went up, but the work was only in a small, disease‑specific group.