[Effect of peptide Livagen on activity of digestive enzymes in gastrointestinal tract and non-digestive organs in rats of different ages].
Timofeeva. N M NM; Khavinson. V Kh VKh; Malinin. V V VV; Nikitina. A A AA; Egorova. V V VV
Key Findings
- Livagen is poorly hydrolyzed by small‑intestine enzymes
- In vitro Livagen cuts glycil‑L‑leucine dipeptidase activity by ~50%
- Two‑week oral Livagen lowers digestive enzyme activity in young rats but raises it in old rats toward youthful levels
Practical Outcomes
- The main takeaway is that Livagen may help restore digestive enzyme activity in older individuals, but the evidence is limited to rats and no human dosing or safety data exist. Biohackers should view this as an interesting lead rather than a ready supplement, and await further research before trying it.
Summary
Livagen is a short peptide that isn’t broken down much by the gut. In lab tests it cuts the activity of one gut enzyme by half. When given to rats for two weeks, it lowered digestive enzyme activity in young rats but boosted it in older rats, bringing the older rats’ enzyme levels close to those of young healthy rats. The study is in animals only, so it’s not a ready‑to‑use protocol for people.
Abstract
It is stated that Livagen (Lys-Glu-Asp-Ala) is a weakly hydrolyzed peptide. Peptide hydrolases of small intestine do not hydrolyze Livagen even to a small extent. Under in vitro conditions Livagen reduces glycil-L-leucinedipeptidase activity in small intestine by 50%. After two weeks of Livagen administration per os in rats the digestive enzymes activity in young animals reduces, while in old animals it increases. It should be mentioned that the activity of enzymes in old rats after Livagen administration in the majority of cases approaches to the level of the activity in young animals of control group.
Study Information
pubmed
2005