[The influence of polypeptide liver complex and tetrapeptide KEDA on organism physiological function in norm and age-related pathology.].
Kuznik. B I BI; Khasanova. N B NB; Ryzhak. G A GA; Mezsheriakova. I E IE; Khavinson. V K VK
Key Findings
- Ventvil and KEDA peptide reduced liver fibrosis, acute and chronic hepatitis in animal models.
- Both peptides normalized antioxidant levels and immune markers, suggesting hepatoprotective and immunoprotective actions.
- The protective effects were most pronounced in aged animals, indicating potential anti‑aging benefits for the liver.
Practical Outcomes
- For biohackers interested in liver health, Livagen may be worth monitoring as a potential supplement, but current evidence is limited to pre‑clinical studies. Until human data are available, any use should be cautious, start with low doses, and be combined with standard liver‑support strategies (e.g., diet, reduced drug load).
Summary
The paper reviews animal and cell‑culture studies showing that a liver‑derived polypeptide mix (Ventvil) and a short peptide called KEDA (Livagen) can protect the liver, boost immune function, and reduce age‑related liver damage. The results are promising but come from pre‑clinical models, not human trials.
Abstract
The applying of many drugs in elderly and old people often is the reason of liver dysfunction. Thereat, the risk of liver fibroid induration, acute and chronic hepatitis increases during aging. It is the reason to find new, effective and harmless hepatoprotectors. In the review is shown the data of hepatoprotective, immunoprotective and antiageing properties of liver polypeptide complex (Ventvil) and KEDA tetrapeptide (Lys-Glu-Asp-Ala, Livagen). In liver pathology experimental models (liver fibroid induration, acute and chronic hepatitis) in amimals and in vitro was shown high efficiency of Ventvil and KEDA peptide. Ventvil and KEDA peptide had concordant effects - normalized immune and antioxidant status, restored liver function during hepatitis. It was demonstrated, that maximal hepato- and immunoprotective effect of peptides verified in aging.
Study Information
pubmed
2020