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Cathelicidin, hCAP-18, FALL-39, CAP-18
An antimicrobial peptide of the cathelicidin family that provides innate immune defense by killing pathogens and modulating inflammation and wound healing.
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Topical
0.5-3.2 mg/mL
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Intravenous (IV)
5 mg/kg (animal models)
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Subcutaneous (SC)
1-10 mg/kg (animal models)
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How It Works: LL-37 functions as a key component of the innate immune system, primarily by directly disrupting microbial membranes and secondarily by regulating host immune responses to enhance defense and repair.
Lian. Zheng Jie ZJ; Nhu. Nguyen Thi Khanh NTK; Ravi. Chitra C; Chang. Chyden C;...
Scientists found that certain E. coli bacteria carry plasmids (small DNA circles) that not only make them resistant to many antibiotics but also help them dodge the body’s natural antimicrobial peptide LL‑37, which is part of the immune defense in the urinary tract.
Chow. Billy Kwok Chong BKC; Choi. Ye Gi YG; Wong. Trevor K TK; Nawabjan. Shaik A...
In mice, a skin‑irritating peptide called LL‑37 creates rosacea‑like redness, swelling, and itching. Blocking the mast‑cell receptor MRGPRX2/B2 with a new compound (GE1111) cuts down these skin problems, lowers inflammation markers, and protects the skin barrier. The effect was seen both in live mice and in cell‑culture tests, showing the drug stops mast cells from over‑reacting with skin cells and immune cells.
Albaz. Ali Can AC; Kosova. Funda F; Temeltaş. Gökhan G; Üçe...
A study measured several blood proteins, including the antimicrobial peptide LL‑37, in people with diabetes‑related urinary leakage, people with leakage but no diabetes, and healthy volunteers. Only one marker, a lipid‑peroxidation product called 4‑HNE, was lower in the diabetic group; LL‑37 and the other proteins showed no meaningful differences.