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Melanotan-I

Afamelanotide, MT-I, [Nle4-D-Phe7]-α-MSH, Scenesse, CUV-1647

A synthetic analog of alpha-melanocyte-stimulating hormone that stimulates melanogenesis, increasing skin pigmentation and providing photoprotection against UV radiation.

Molecular Profile
Formula C78H111N21O19
Mol. Weight 1646.9 g/mol
Sequence Gly-Glu-Pro-Pro...
Clinical Data Trials
Scientific Data Studies
Route
Subcutaneous (SC)
0.16 mg/kg
SUB
Oral
Not effective
ORA
Subcutaneous Implant
16 mg
SUB

How It Works

How It Works: Melanotan I acts as an agonist of melanocortin receptors, primarily MC1R, mimicking α-MSH to stimulate melanin production in melanocytes, leading to skin tanning and enhanced UV protection.

  • Binds to MC1R on melanocytes, activating adenylate cyclase and increasing intracellular cAMP levels.
  • Upregulates tyrosinase and other enzymes involved in eumelanin synthesis, promoting pigmentation.
  • Provides photoprotection by absorbing UV radiation and reducing DNA damage in skin cells.

Pairs Well With

TB
TB-500
Systemic repair
Cu
GHK-Cu
Skin & collagen
KP
KPV
Anti-inflammatory
Ip
Ipamorelin
GH secretagogue

Latest Clinical Trials

Completed PHASE1 NCT00345670

Study to Evaluate the Safety of MEDI-534 Vaccine Against Respiratory Syncytial Virus (RSV) and Parainfluenza Virus Type 3 (PIV3) in Healthy Children

MedImmune LLC
INTERVENTIONAL
Updated Dec 15, 2025
Completed PHASE3 NCT04392154

Long-term Safety and Efficacy Study of Lebrikizumab (LY3650150) in Participants With Moderate-to-Severe Atopic Dermatitis (ADjoin)

Eli Lilly and Company
INTERVENTIONAL
Updated Dec 15, 2025
Completed PHASE3 NCT01225562

Prevention of Cardiovascular Events (eg, Death From Heart or Vascular Disease, Heart Attack, or Stroke) in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin

AstraZeneca
INTERVENTIONAL
Updated Dec 15, 2025
View All Clinical Trials

Latest Studies

Utility 3
pubmed May 6, 2025

A single-centre, prospective, qualitative analysis of knowledge, attitudes and behaviour of sunbed use among patients attending a pigmented lesion clinic in a tertiary referral centre.

Lai. Fei Ya FY; Quigley. Claire C; Murray. Gregg G; Gordon. Amanda A; Yong. Ji F...

The study looked at people who go to tanning salons and found that many also use the unregulated peptide Melanotan I to boost their tan. Even though most know tanning can cause skin cancer, they keep using sunbeds and the peptide, often in places that don’t follow safety rules. This suggests a habit‑like behavior that may need psychological help and stricter regulation.

Utility 2
pubmed Aug 28, 2024

Melanocortin Receptor Agonist Bremelanotide Induces Cell Death and Growth Inhibition in Glioblastoma Cells <i>via</i> Suppression of Survivin Expression.

Suzuki. Shuhei S; Kitanaka. Chifumi C; Okada. Masashi M

In lab tests, the peptide bremelanotide (also known as melanotan‑I) was able to kill glioblastoma brain‑cancer cells by lowering a protein called survivin, without harming normal human cells. The effect depended on activating specific melanocortin receptors (MC3 and MC4) and could boost the killing power of standard chemo drugs.

Utility 1
pubmed Aug 26, 2024

Recommended Tool Compounds for the Melanocortin Receptor (MCR) G Protein-Coupled Receptors (GPCRs).

Weirath. Nicholas A NA; Haskell-Luevano. Carrie C

This review talks about a handful of synthetic peptides (like melanotan I, melanotan II, and SHU9119) that scientists use as research tools to study melanocortin receptors, which are involved in skin color, hormone production, and energy balance. It explains how these compounds help map receptor structures and guide drug discovery, but it doesn't give any practical advice on how to use them in humans.

Browse All Studies