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Melanotan-I

Afamelanotide, MT-I, [Nle4-D-Phe7]-α-MSH, Scenesse, CUV-1647

Quick Stats
Studies 225
Trials 100
Score 3
2025 pubmed

A single-centre, prospective, qualitative analysis of knowledge, attitudes and behaviour of sunbed use among patients attending a pigmented lesion clinic in a tertiary referral centre.

Lai. Fei Ya FY; Quigley. Claire C; Murray. Gregg G; Gordon. Amanda A; Yong. Ji Fung JF; Yoo. Helena H; Howard-James. Claudine C; Impey. Kelly K; Blake. Carmel C; Tobin. Anne-Marie AM

Key Findings

  • Sunbed users frequently also use Melanotan I, linking the peptide to indoor tanning habits
  • More than half of tanning salons lack basic safety measures like protective goggles or health warnings
  • Awareness of skin‑cancer risks does not reduce tanning or peptide use, indicating possible addictive behavior

Practical Outcomes

  • For biohackers, the takeaway is that using Melanotan I, especially with sunbeds, carries added health risks and may be part of a compulsive pattern. Seek safer, regulated alternatives and consider professional advice before using unapproved tanning agents.

Summary

The study looked at people who go to tanning salons and found that many also use the unregulated peptide Melanotan I to boost their tan. Even though most know tanning can cause skin cancer, they keep using sunbeds and the peptide, often in places that don’t follow safety rules. This suggests a habit‑like behavior that may need psychological help and stricter regulation.

Abstract

Indoor tanning through sunbeds is linked to a heightened risk of skin cancers, particularly cutaneous squamous cell carcinoma and basal cell carcinoma, with significant increases in risk for users aged < 35 years. Despite regulations established by the Public Health (Sunbeds) Act 2014 in Ireland, sunbed use persists, primarily for cosmetic reasons. To analyse the characteristics, attitudes and behaviours of sunbed users attending an Irish dermatology outpatient clinic. We undertook a prospective qualitative analysis of 104 consecutive patients attending a pigmented lesion clinic in a tertiary referral dermatology department in Ireland. This was done using a self-reported anonymous survey where respondents answered questions relating to their own demographic data, frequency of sunbed use, motivation for sunbed use and use of unregulated tan-enhancing agents (namely Melanotan I and II). The results showed that patient demographics were consistent with previous studies on sunbeds use, namely younger female patients living in urban areas. Many sunbed premises did not comply with safety regulations; over half lacked protective goggles, and nearly half received no health risk information. The reasons for sunbed use included improving appearance and confidence, with a significant number using tan-enhancing agents. Surprisingly, increased awareness of health risks did not correlate with reduced usage; many users continued tanning practices despite concerns about its adverse effects. Users of tan-enhancing agents also used sunbeds more frequently compared with nonusers. This study suggests a potential psychopathological aspect of tanning behaviours similar to addictive disorders like smoking and alcohol. Patients may benefit from psychological and behavioural interventions such as cognitive behavioural therapy to address their compulsive behaviour. Furthermore, there was a concerning lack of compliance with regulations in tanning salons, highlighting a public health issue. The rising use of unregulated tanning agents, especially among younger people, poses additional risks, including blood-borne infections. This study underscores the need for targeted educational interventions among younger age groups and stricter enforcement of regulations to mitigate health risks associated with indoor tanning. Understanding the complex motivations behind sunbed use is crucial for developing effective strategies to reduce its prevalence and promote safer alternatives.

Study Information

Provider

pubmed

Year

2025

Date

2025-05-06T00:00:00.000Z

DOI

10.1093/skinhd/vzaf014