Menu
Submit Data
Peptide Database
Results
No peptides found
Featured

Use search to browse all 100+ peptides

Back to Studies

Melanotan-I

Afamelanotide, MT-I, [Nle4-D-Phe7]-α-MSH, Scenesse, CUV-1647

Quick Stats
Studies 225
Trials 100
Overview Studies Clinical Trials
1992 pubmed

Analysis of autofeedback mechanisms in the secretion of pro-opiomelanocortin-derived peptides by melanotrope cells of Xenopus laevis.

de Koning. H P HP; Jenks. B G BG; Scheenen. W J WJ; Balm. P H PH; Roubos. E W EW

View on DOI View Original Source

Key Findings

  • Alpha‑MSH and a strong synthetic version did not change the release of POMC‑derived peptides in frog pituitary tissue
  • Melanin concentrating hormone did not affect alpha‑MSH secretion
  • A mixture of POMC‑derived peptides in the superfusate did not alter melanotrope cell activity

Practical Outcomes

  • These results don’t give any actionable advice for human use of melanotan‑I. The lack of autofeedback in frogs doesn’t translate to dosing or safety guidance for biohackers, so the study has essentially no practical relevance for longevity or performance protocols.

Summary

The study looked at frog pituitary cells and found that the hormone alpha‑MSH (similar to melanotan‑I) does not control its own release or that of related peptides, meaning there’s no short‑term feedback loop in this animal model.

Abstract

The secretion of most pituitary hormones is under the control of feedback mechanisms. The feedback control of alpha-melanophore-stimulating hormone (alpha-MSH) from melanotrope cells is controversial. The possible existence of an autofeedback exerted by alpha-MSH or other POMC-derived peptides on melanotrope cells of the amphibian Xenopus laevis has been investigated. alpha-MSH or its potent agonist 4-norleucine,7-D-phenylalanine-alpha-MSH has no effect on the release of radiolabeled POMC-derived peptides or immunoreactive beta-endorphin from superfused neurointermediate pituitary lobes. Melanin concentrating hormone, previously reported to have an alpha-MSH-like effect on melanophores, did not affect alpha-MSH secretion. Neurointermediate lobe superfusate, which contains a mixture of POMC-derived peptides, failed to affect the secretory activity of melanotropes. It is concluded that in X. laevis the secretory activity of melanotropes is not under the control of short-term autofeedback mechanisms involving alpha-MSH or other POMC-derived peptides.

Study Information

Provider

pubmed

Year

1992

DOI

10.1016/0016-6480(92)90046-m