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Melanotan-I

Afamelanotide, MT-I, [Nle4-D-Phe7]-α-MSH, Scenesse, CUV-1647

Quick Stats
Studies 225
Trials 100
Overview Studies Clinical Trials
Score 2
2006 pubmed

Change in gene expression profile induced by alpha-melanocyte stimulating hormone in a malignant mesothelioma cell line.

Colombo. G G; Sordi. A A; Turcatti. F F; Carlin. A A; Rossi. C C; Lonati. C C; Santambrogio. L L; Gatti. S S; Catania. A A

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Key Findings

  • NDP‑alpha‑MSH lowered the activity of oncogenes Myc and B‑Myb in malignant mesothelioma cells
  • It altered integrin‑related pathways, which may affect how cells stick and move
  • The peptide strongly reduced the inflammatory cytokine IL‑13, which can promote tumors

Practical Outcomes

  • The findings hint that alpha‑MSH analogs might have anti‑cancer properties, but there’s no dosage, safety, or human data yet. For biohackers, it’s not a ready‑to‑use protocol, just a mechanistic clue that more research is needed before any real‑world application.

Summary

A lab study found that a synthetic version of the hormone alpha‑MSH can slow the growth of a cancer cell line by turning off key genes that drive cell division and inflammation, but this was only tested in petri dishes, not in people.

Abstract

We have previously reported that the peptide a-melanocyte stimulating hormone (alpha-MSH) has antiproliferative effects in human malignant mesothelioma cells. To determine the molecular mechanisms underlying such effects, we investigated the changes in gene expression profile induced by the alpha-MSH analog [Nle4 -DPhe7 ]-alpha-MSH (NDP-alpha-MSH) in a human malignant mesothelioma cell line. The cDNA macroarray technique revealed changes in expression of genes involved in cell growth, adhesion, signal transduction, and transcription. In particular, NDP-alpha-MSH down-regulated expression of B-Myb and Myc, two oncogenes considered of paramount importance for cell proliferation and cancer. Further, NDP-alpha-MSH exerted a favorable transcriptional regulation of certain integrins and their signaling pathways. Finally, peptide treatment was associated with a prominent inhibition of IL-13, a cytokine with tumor-promoting effects. The data indicate that the influences of alpha-MSH extend beyond the established anti-inflammatory effects in normal cells to include cell cycle regulatory properties in malignant cells.

Study Information

Provider

pubmed

Year

2006

Date

2006-05-30T00:00:00.000Z