[The effect of alpha-melanocyte-stimulating hormone and its analog on the growth of human melanoma cell lines with different phenotypes].
Morozova. L F LF; D'iakov. V L VL; Sukhanov. V A VA
Key Findings
- The analog (NLe4, D-Phe7)-alphaâMSH boosted growth of amelanotic BRO melanoma cells by 1.5â2.5Ă at concentrations from 10â»â¶ to 10â»ÂčÂČâŻM.
- The same analog inhibited growth of melaninâproducing MS melanoma cells under identical conditions.
- No impact on the growth of human lung fibroblast cells was observed.
Practical Outcomes
- Because the peptide can stimulate growth of certain melanoma cells, users should be cautious, especially if they have a history or risk of amelanotic skin cancer. The findings donât provide a new dosing guide, but they highlight a potential safety concern that warrants further research before longâterm or highâdose use.
Summary
The study shows that a synthetic version of alphaâMSH (the same type of peptide used in melanotanâI) can make some melanoma cells grow faster while slowing down others, and it doesnât affect normal lung cells. This means the peptide isnât uniformly safe or harmful for skin cancer cells, and the effect depends on the cellâs melanin type.
Abstract
Investigation of physiological effects of alpha-MSH and its analog (NLe4, D-Phe7)-alpha-MSH on human melanoma cells with different phenotypes has shown that these peptides have a growth-modulating activity. The effect of inhibition or activation of the growth of melanoma cells depended on their phenotypes. (NLe4, D-Phe7)-alpha-MSH activated 1.5-2.5-fold the growth of amelanotic BRO cells at concentrations of 10(-6)-10(-12) M, but inhibited the growth of melanin-producing MS cells under the same conditions not affecting the growth of human lung fibroblasts.
Study Information
pubmed
1993