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MGF Igf-1-ec

IGF-1Ec, IGF-1Eb, Mechano-Growth Factor

Quick Stats
Studies 62
Trials 100
Completed NA INTERVENTIONAL NCT01971723

Multi-ingredient Supplement for Strength and Power

View on ClinicalTrials.gov Updated Dec 15, 2025

Brief Summary

It has been suggested that high amounts of total serum testosterone levels correlate with higher lean body mass, lowered fat mass, greater muscle strength, and faster recovery. These suggestions drive athletes and body builders to find ways to raise their testosterone levels. Many athletes and bodybuilders look to alternative methods to anabolic steroids in order increase their testosterone levels without legal repercussions or physiological side effects. Herbs and other plant extracts have been introduced as a possible source to naturally boost testosterone levels. Research supporting the use of herbs and plant extracts has been shown to be equivocal. However, evidence in studies with hypogonadal men suggests that longjack root may naturally boost testosterone levels. Onnit Labs, LLC has packaged this supplement (T+) which claims it can naturally boost testosterone and lower estrogen levels and subsequently improve performance. This product is a powder (11g) that is mixed with 16 oz of water and consumed 20 minutes prior to anaerobic workouts, such as high intensity weight training. T+ is a multi-ingredient supplement that consists of vitamins B5 and B6, magnesium aspartic acid, mucuna pruriens, longjack root, nettle root, red clover luteolin, resveratrol, beta- alanine, branch chain amino acids, L- glutamine, Bioperine, and Fibersol 2. The active ingredients purported to boost plasma testosterone levels are mucuna pruriens, longjack root, and magnesium aspartic acid. The active ingredients claimed to lower plasma estrogen concentrations are red clover, luteolin, resveratrol and nettle root. All other ingredients (Branch Chain Amino Acids and Beta-Alanine) have been documented to improve exercise performance. It is hypothesized that there will not be any physiological changes after supplementation of T+. It is also hypothesized that performance will not be affected by the supplementation of T+.

Detailed Description

The purpose of this study is to examine the physiological and performance effects of T+ on power athletes.

Interventions

Name: T+ Supplement
Type: OTHER
Description: Randomized, placebo-controlled, double blind protocol with two treatment groups (matched by lean body mass). Group 1 will receive the recommended serving of one scoop (11g) of T+ supplement. This serving will be taken 45 minutes before the beginning of working out on an empty stomach (\>1 hour after meal). On non-training days, the participants will also take a serving at the same time as on training days. This will continue for four weeks (28 days).
Name: Placebo
Type: OTHER
Description: The placebo group will consume a calorie-match placebo in the same manner as the supplement group (one serving 45 minutes prior to work outs on an empty stomach). The placebo group will also follow the same supplementation patterns and workout as their counterparts in the supplement group.

Primary Outcomes

Measure: Strength Performance Outcomes
TimeFrame: Baseline measures and 4 weeks from start of study
Description: Measurement of one repetition maximums strength for all competition lifts included in a standard, ungeared, powerlifting competition (squat, bench, and deadlift). This testing will take place before the supplementation of either T+ or placebo and at the end of the four-week training period. Each measure was only compared within it's own category against the baseline measurement and against that of the other group at the same time point.
Measure: Insulin Outcomes
TimeFrame: Baseline, 2-week mark, 4-week mark
Description: Measurements of insulin will occur on three occasions: prior to the start of supplementation and training, at the end of two weeks, and finally at the end of training.
Measure: Blood Lipid Outcomes
TimeFrame: Baseline, 2-week mark, 4-week mark
Description: Measurements for blood lipid panels will occur on three occasions: prior to the start of supplementation and training, at the end of two weeks, and finally at the end of training.
Measure: Total Testosterone Outcomes
TimeFrame: Baseline, 2-week mark, 4-week mark
Description: Measurements for testosterone will occur on three occasions: prior to the start of supplementation and training, at the end of two weeks, and finally at the end of training.
Measure: Estrogen Outcomes
TimeFrame: Baseline, 2-week mark, 4-week mark
Description: Measurements for estrogen will occur on three occasions: prior to the start of supplementation and training, at the end of two weeks, and finally at the end of training.
Measure: Insulin-like Growth Factor-I Outcomes
TimeFrame: Baseline, 2-week mark, 4-week mark
Description: Measurements for insulin-like growth factor-I will occur on three occasions: prior to the start of supplementation and training, at the end of two weeks, and finally at the end of training.
Measure: Bio-availableTestosterone Outcomes
TimeFrame: Baseline, 2-week mark, 4-week mark
Description: Measurements for total testosterone will occur on three occasions: prior to the start of supplementation and training, at the end of two weeks, and finally at the end of training.
Measure: Free Testosterone Outcomes
TimeFrame: Baseline, 2-week mark, 4-week mark
Description: Measurements for free testosterone will occur on three occasions: prior to the start of supplementation and training, at the end of two weeks, and finally at the end of training.
Measure: Dihydrotestosterone Outcomes
TimeFrame: Baseline, 2-week mark, 4-week mark
Description: Measurements for dihydrotestosterone (DHT) will occur on three occasions: prior to the start of supplementation and training, at the end of two weeks, and finally at the end of training.
Measure: Cortisol Outcomes
TimeFrame: Baseline, 2-week mark, 4-week mark
Description:
Measure: Sex-hormone Binding Globulin Outcomes
TimeFrame: Baseline, 2-week mark, 4-week mark
Description:
Measure: Creatine-Kinase Outcomes
TimeFrame: Baseline, 2-week mark, 4-week mark
Description:

Trial Information

NCT ID

NCT01971723

Status

Completed

Study Type

INTERVENTIONAL

Phases

NA

Sponsor

Florida State University

Last Updated

December 15, 2025