MGF Igf-1-ec

IGF-1Ec, IGF-1Eb, Mechano-Growth Factor

A splice variant of IGF-1 that promotes muscle repair, hypertrophy, and satellite cell activation in response to mechanical stress or damage.

Molecular Profile

Formula C₁₂₁H₂₀₀N₄₀O₄₀

Mol. Weight 2888.16 g/mol

Sequence Gly-Glu-Pro-Pro...

Clinical Data Trials

Scientific Data Studies

Route	Dosage	Bioavailability
Subcutaneous (SC) 200-400 mcg	200-400 mcg	High (95%)	SUB
Intramuscular (IM) 100-300 mcg	100-300 mcg	Very High (98%)	INT
Intravenous (IV, animal studies) 50-100 mcg/kg	50-100 mcg/kg	Complete (100%)	INT

How It Works

How It Works: MGF is produced in muscle tissue following damage or overload, acting locally to initiate repair processes by activating satellite cells and promoting proliferation without the need for the IGF-1 receptor in some actions.

Satellite Cell Activation: Stimulates proliferation of muscle stem cells to replenish damaged muscle fibers.
Muscle Hypertrophy: Enhances myoblast fusion and differentiation, leading to increased muscle mass.
Neuroprotection: Exhibits protective effects on neurons, aiding in tissue repair beyond muscle.
Anti-Apoptotic Effects: Prevents cell death in damaged tissues, supporting regeneration.

Pairs Well With

Latest Clinical Trials

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Not Yet Recruiting PHASE2 NCT05703997

FASTing-like Approach and Maintenance IMMunotherapy in ES-SCLC Patients Not Progressing on Chemoimmunotherapy Induction

Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

INTERVENTIONAL

Updated Dec 15, 2025

Completed NCT01738776

Nutritional Risk Factors for Hip Fracture: a Case Control Study

Oslo University Hospital

OBSERVATIONAL

Updated Dec 15, 2025

Completed NA NCT05501249

Aquatic Exercise for Cognition and Mobility in Older Adults

Emily Dunlap

INTERVENTIONAL

Updated Dec 15, 2025

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Latest Studies

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Utility 2

pubmed Jul 25, 2024

Mechano-growth factor regulates periodontal ligament stem cell proliferation and differentiation through Fyn-RhoA-YAP signaling.

Feng. Fan F; Tu. Teng T; Wang. Hui H; Song. Runfang R; Li. Junrong J; Zhu. Yue Y...

The study shows that a protein called Mechano‑Growth Factor (MGF) can make gum‑line stem cells grow and turn into tissue‑building cells by activating a specific chain of signals (Fyn‑RhoA‑YAP). This effect was seen in lab dishes, not in people, and it doesn’t involve the usual LATS1‑YAP route.

Utility 2

pubmed Dec 8, 2022

The Roles of IGF-1 and MGF on Nerve Regeneration under Hypoxia- Ischemia, Inflammation, Oxidative Stress, and Physical Trauma.

Sha. Yongqiang Y; Chen. Liping L; Xu. Chunming C; Zhang. Beibei B; Hong. Huhai H...

The review says that IGF‑1 and its variant MGF can help nerves heal after damage, especially when the tissue is low on oxygen, inflamed, or under oxidative stress. They work by promoting cell growth and preventing cell death, which could speed up nerve repair.

Utility 2

pubmed Sep 23, 2020

Role of Alternatively Spliced Messenger RNA (mRNA) Isoforms of the Insulin-Like Growth Factor 1 (IGF1) in Selected Human Tumors.

Kasprzak. Aldona A; Szaflarski. Witold W

The paper reviews how different versions of the IGF‑1 gene (including the MGF/IGF‑1Ec peptide) are made in the body and how they act in normal tissues like muscle and brain, as well as in various cancers. It explains that the same peptide that helps muscle repair can also be found in tumors, suggesting a double‑edged role.

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