The Roles of IGF-1 and MGF on Nerve Regeneration under Hypoxia- Ischemia, Inflammation, Oxidative Stress, and Physical Trauma.
Sha. Yongqiang Y; Chen. Liping L; Xu. Chunming C; Zhang. Beibei B; Hong. Huhai H; Wang. Chunli C
Key Findings
- IGF‑1 and MGF have strong proliferative and anti‑apoptotic effects on neurons in harsh environments.
- Both peptides improve neural survival and myelin regeneration after injuries such as hypoxia‑ischemia, inflammation, and oxidative stress.
- Cytokine therapy using IGF‑1/MGF is highlighted as a promising approach for accelerating nerve repair.
Practical Outcomes
- For self‑experimenters, the take‑away is that IGF‑1/MGF may be worth exploring as part of a nerve‑support regimen, especially after injuries or conditions that limit oxygen and increase inflammation. However, the paper does not give specific dosing or administration guidelines, so any use should start with low, well‑tolerated doses and consider safety data from other studies.
Summary
The review says that IGF‑1 and its variant MGF can help nerves heal after damage, especially when the tissue is low on oxygen, inflamed, or under oxidative stress. They work by promoting cell growth and preventing cell death, which could speed up nerve repair.
Abstract
Nerve injuries and lesions often lead to the loss of neural control, reducing the patients' quality of lives. Nerve self-repair is difficult due to the low regeneration capacity, insufficient secretion of neurotrophic factors, secondary complications, and adverse microenvironmental conditions such as severe hypoxia-ischemia, inflammation, and oxidative stress. Effective therapies that can accelerate nerve regeneration have been explored. Cytokine therapy can significantly improve neural survival and myelin regeneration during nerve repair. Insulin-like growth factor-1 (IGF-1) and its isoforms (IGF- 1Ea and IGF-1Eb/Ec [also known as MGF]) represent a promising therapeutic approach regarding nerve repair, given their well-described proliferative and anti-apoptotic capacities on neurons withstanding the adverse environmental conditions. This review summarizes the research progress regarding the effects of IGF-1 and its isoforms on nerve repair after nerve injury, hypoxic-ischemic insult, inflammation, and oxidative stress. We provide a theoretical basis for the clinical treatment of nerve injuries.
Study Information
pubmed
2023
2022-12-08T00:00:00.000Z
10.2174/1389203724666221208145549
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