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MGF Igf-1-ec

IGF-1Ec, IGF-1Eb, Mechano-Growth Factor

Quick Stats
Studies 62
Trials 100
Completed NA INTERVENTIONAL NCT00871455

Effect of Low-Dose Baclofen Administration on the GH-IGF1 Axis Study

View on ClinicalTrials.gov Updated Dec 15, 2025

Brief Summary

Insulin-like growth factor I (IGF-I) is used as a measure of the body's ability to produce growth hormone. Growth hormone is important for muscle tissue as well as many other tissues in the body. Growth hormone (GH) and IGF-I have been shown to be reduced in many persons with SCI. Baclofen is a FDA approved drug that is used to treat spasticity. Persons receiving long-term baclofen therapy have been demonstrated to have increased growth hormone and IGF-I levels. IGF-I levels will be determined before and after treatment with baclofen. In this study, the investigators will determine the minimum dose of baclofen at which improvements in GH and IGF-1 levels occur.

Interventions

Name: Baclofen
Type: DRUG
Description: Subjects will receive 20 mg baclofen for 8 weeks, followed by 40 mg baclofen for 8 weeks.

Primary Outcomes

Measure: Determine the threshold dose 20 or 40 mg/d of baclofen and the dose-response curve of the medication for its effect to raise plasma IGF-1 levels
TimeFrame: 20-week (5 months) in which subjects are asked to report for 12 visits after starting baclofen therapy
Description:

Trial Information

NCT ID

NCT00871455

Status

Completed

Study Type

INTERVENTIONAL

Phases

NA

Sponsor

US Department of Veterans Affairs

Last Updated

December 15, 2025