MGF Igf-1-ec

IGF-1Ec, IGF-1Eb, Mechano-Growth Factor

A splice variant of IGF-1 that promotes muscle repair, hypertrophy, and satellite cell activation in response to mechanical stress or damage.

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Studies 62

Trials 100

Formula C₁₂₁H₂₀₀N₄₀O₄₀

Overview Studies 62 Clinical Trials 100

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pubmed Sep 11, 2012

In vitro cytocompatibility evaluation of MGF-Ct24E chemically grafted and physically blended with maleic anhydride modified poly(D, L-lactic acid).

Li. Yuxiao Y; Wang. Yuanliang Y; Wang. Pinpin P; Zhang. Bingbing B; Yan. Weiwei W; Sun. Jiaoxia J; P...

Scientists attached a bone‑growth peptide (MGF‑Ct24E) to a biodegradable plastic and tested it with rat bone cells in the lab. The peptide‑coated material helped the cells stick, spread, multiply, and later form bone‑like mineral, especially when the peptide was chemically bonded rather than just mixed in. However, this work is about a lab‑made scaffold, not a supplement or protocol you can use yourself.

pubmed Mar 28, 2019

Mechano growth factor attenuates mechanical overload-induced nucleus pulposus cell apoptosis through inhibiting the p38 MAPK pathway.

Xu. Qing Q; Fang. Haolin H; Zhao. Liang L; Zhang. Cunxin C; Zhang. Luo L; Tian. Baofang B

A lab study in rats showed that a peptide called Mechano Growth Factor (MGF) can protect the soft inner part of spinal discs from dying when they’re stressed by too much mechanical load. It does this by lowering the activity of a stress‑related pathway (p38 MAPK) and reducing cell‑death signals. The work is early‑stage and done in cell cultures, not people.