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Mots-C

Mitochondrial open reading frame of the 12S rRNA-c, MT-RNR1, Mitochondrial-derived peptide MOTS-c

A 16-amino acid mitochondrial-derived peptide that regulates metabolic homeostasis, enhances insulin sensitivity, and promotes longevity.

Molecular Profile
Formula C101H152N28O22S2
Mol. Weight 2174.64 g/mol
Sequence Gly-Glu-Pro-Pro...
Clinical Data Trials
Scientific Data Studies
Route
Intraperitoneal (IP, animal)
0.5-5 mg/kg/day
INT
Subcutaneous (SC)
200-1000 mcg/day
SUB

How It Works

How It Works: MOTS-c is a mitochondrial-derived peptide that translocates to the nucleus under stress, regulating gene expression to maintain metabolic balance and activate AMPK pathways.

  • Inhibits folate cycle and purine biosynthesis, leading to AICAR accumulation and AMPK activation
  • Enhances glucose uptake, fatty acid oxidation, and insulin sensitivity in skeletal muscle
  • Reduces inflammation and protects against oxidative stress
  • Promotes mitochondrial function and energy expenditure, preventing obesity and age-related metabolic decline.

Pairs Well With

TB
TB-500
Systemic repair
Cu
GHK-Cu
Skin & collagen
KP
KPV
Anti-inflammatory
Ip
Ipamorelin
GH secretagogue

Latest Clinical Trials

Active Not Recruiting NA NCT04013568

Exercise Post-Diagnosis of Breast Cancer

University of Hawaii
INTERVENTIONAL
Updated Dec 15, 2025
Active Not Recruiting NCT06133946

Cohort Of DEafness-gene Screening

Affiliated Hospital of Nantong University
OBSERVATIONAL
Updated Dec 15, 2025
Unknown NCT04027712

Platelet Reactivity, B-amyloid, MOTS-c and Mortality of Type II Diabetics With CAD

University of Athens
OBSERVATIONAL
Updated Dec 15, 2025
View All Clinical Trials

Latest Studies

Utility 2
pubmed Dec 10, 2025

Circulating Mitochondrial Open Reading Frame of the 12S Ribosomal RNA Type-c Is Higher in Acute Coronary Syndrome and Is a Prognostic Biomarker for Major Cardiac Events in Patients With Acute Myocardial Infarction: A Case-Control Study.

Cao. Pengyu P; Wang. Bojian B; Zhang. Ningning N; Yang. Jinting J; Tong. Qian Q;...

The study found that people with acute coronary events (like heart attacks) have higher blood levels of the peptide MOTS‑c, and these levels rise together with markers of oxidative stress. High MOTS‑c can help predict who will have a heart attack or unstable angina, and in patients who already had a heart attack, the ratio of MOTS‑c to oxidative‑stress markers may forecast future serious heart problems.

Utility 3
pubmed Nov 21, 2025

MOTS‑c protects against placental injury via Nrf2 activation in hypoxia‑induced intrauterine growth restriction mice.

Chen. Dan D; Zhao. Hui-Min HM; Sun. Xiao-Lin XL; Xing. Zhi-Xuan ZX; Li. Sheng-Pe...

In a mouse study, giving the tiny peptide MOTS‑c helped protect the placenta from low‑oxygen damage and let babies grow bigger by boosting blood‑vessel growth and cutting oxidative stress, but only when the Nrf2 antioxidant pathway was working. This suggests MOTS‑c can turn on Nrf2, a key defender against oxidative damage, though the work was done in pregnant mice, not people.

Utility 3
pubmed Oct 11, 2025

MOTS-c in type 2 diabetes mellitus: From risk factors to cardiac complications and potential treatment.

Fang. Tingting T; Han. June-Chiew JC; Taberner. Andrew A; Pham. Toan T

The review explains that the tiny protein MOTS‑c, made by mitochondria, is often low in people with type‑2 diabetes and may contribute to the disease and heart problems. Lab studies in animals show that giving extra MOTS‑c can improve blood sugar control, boost metabolism, and protect the heart, and researchers have tried several doses and timing schedules. However, there are no human trials yet, so the information is mostly a guide for future experiments rather than a ready‑to‑use supplement plan.

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