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Mots-C

Mitochondrial open reading frame of the 12S rRNA-c, MT-RNR1, Mitochondrial-derived peptide MOTS-c

Quick Stats
Studies 137
Trials 5
Active Not Recruiting NA INTERVENTIONAL NCT04013568

Exercise Post-Diagnosis of Breast Cancer

View on ClinicalTrials.gov Updated Dec 15, 2025

Brief Summary

The investigators are doing this study to determine if there are body composition changes after a 12-week exercise program in breast cancer patients and determine what factors contribute to sustained physical activity after the 12-week exercise program intervention.

Detailed Description

The study is enrolling breast cancer patients up to 2 years after their diagnosis in a 12-week exercise program. The participants will either participate in: Group 1-participating in an exercise program with biometric evaluations or Group 2-biometric evaluations but not participating in the exercise program. At the end of the 12-week exercise program, participants in Group 1 will be randomized to either: a) continuing with exercise group classes or b) continuing with exercise individual classes. Both Group 1a and 1b participants will be followed for the remainder of the year and be evaluated for continued physical activity. All Group study participants' biometrics will be assessed at baseline and at the end of 12-weeks, with continued annual medical review follow-up for a total of 5 years.

Interventions

Name: Exercise
Type: OTHER
Description: First Intervention 12-week exercise program, 3 days/week, 90min exercise sessions at the Rehabilitation Hospital of the Pacific. Private or semi-private (1:1 or 2:1 ratio participant to instructor) sessions, led by Kinesiology students Second Intervention- 12-week exercise program, 2 days/week, 90min exercise sessions at the Rehabilitation Hospital of the Pacific. Group Fitness Classes

Primary Outcomes

Measure: Fat mass
TimeFrame: 1 day
Description: Measure fat mass (arms, legs, trunk and total) in kg using Dual energy X-ray absorptiometry (DXA) data
Measure: Isometric peak torque
TimeFrame: 1 day
Description: Measure the peak torque value generated during isometric knee extension/flexion movement evaluation at 60 degrees will be assessed with the HUMAC NORM device
Measure: Lean mass
TimeFrame: 1 day
Description: Measure lean mass (arms, legs, trunk and total) in kg using Dual energy X-ray absorptiometry (DXA) data
Measure: Bone mass
TimeFrame: 1 day
Description: Measure bone mass (arms, legs, trunk and total) in kg using Dual energy X-ray absorptiometry (DXA) data
Measure: Waist to Hip ratio (WHR) from manual tape measurement
TimeFrame: 1 day
Description: Manual physical anthropometry of waist and hip circumferences
Measure: Automatic 3D optical (3DO) scan measurement: girth measurement
TimeFrame: 1 day
Description: Automated 3DO measurements generate the following: girth in cm measurements across the whole body
Measure: Muscle Function
TimeFrame: 1 day
Description: Measure the peak torque value generated during isometric knee extension/flexion movement evaluation at 60 degrees will be assessed with the HUMAC NORM device
Measure: Percent fat
TimeFrame: 1 day
Description: Percent fat (arms, legs, trunk and total) using Dual energy X-ray absorptiometry (DXA) data
Measure: Automatic 3D optical (3DO) scan measurement: length measurement
TimeFrame: 1 day
Description: Automated 3DO measurements generate the following: length in cm measurements across the whole body
Measure: Automatic 3D optical (3DO) scan measurement: volume measurement
TimeFrame: 1 day
Description: Automated 3DO measurements generate the following: volume in cm measurements across the whole body
Measure: Bone Mineral Density (spine and total) using Dual energy X-ray absorptiometry (DXA) data
TimeFrame: 1 day
Description: Bone Mineral Density (spine and total) using Dual energy X-ray absorptiometry (DXA) data

Trial Information

NCT ID

NCT04013568

Status

Active Not Recruiting

Study Type

INTERVENTIONAL

Phases

NA

Sponsor

University of Hawaii

Last Updated

December 15, 2025