Mots-C
Mitochondrial open reading frame of the 12S rRNA-c, MT-RNR1, Mitochondrial-derived peptide MOTS-c
The Relationship Between MOTS-c K14Q Polymorphism and Sarcopenia, Blood Lipids, and Mental Health in Older Korean Adults.
Kim. Shinuk S
Key Findings
- Men with the C allele had significantly higher appendicular skeletal muscle mass and lean mass than A‑allele men
- C‑allele men showed stronger left and right handgrip strength
- The muscle‑related advantages persisted after adjusting for age, diet, and other factors; no similar effects were seen in women
Practical Outcomes
- If you’re into personalized health, genetic testing for the MOTS‑c K14Q variant could flag men at higher risk of sarcopenia. Those with the risk‑associated A allele might focus more on resistance training, protein intake, or emerging MOTS‑c peptide supplements, though direct supplementation evidence is still lacking.
Summary
A study of older Korean adults found that men with a specific genetic version of the MOTS‑c peptide (the C allele) have more muscle mass and stronger grip compared to men with the common A version, while women showed no difference. This suggests the gene could help predict age‑related muscle loss in men, but it doesn’t test any treatments.
Abstract
<b>Background/objectives:</b> An East Asian-specific 1382A>C polymorphism in the mitochondrial open reading frame of the 12S rRNA type-c results in an amino acid substitution from Lys (K) to Gln (Q) at the 14th amino acid residue. This study investigated the association between m.1382A>C polymorphism and sarcopenia, blood lipids, and mental health in older Korean adults. <b>Methods:</b> The study included 683 community-dwelling Korean adults (345 men and 338 women) aged 65 years and older. The m.1382A>C polymorphism was genotyped with a 7500 real-time PCR system. Handgrip strength (HGS) was measured, and appendicular skeletal muscle (ASM) mass was calculated. Demographics, blood lipids, falling risk, nutritional intake, cognition function, and depression were additionally measured. <b>Results:</b> Men carrying the C allele had significantly higher ASM (21.6 ± 3.0 vs. 19.5 ± 2.2 kg, <i>p</i> = 0.018), ASM/height<sup>2</sup> (7.76 ± 0.76 vs. 7.14 ± 0.62 kg/m<sup>2</sup>, <i>p</i> = 0.012), lean mass (53.3 ± 6.2 vs. 46.5 ± 4.0 kg, <i>p</i> < 0.001), left HGS (33.3 ± 5.0 vs. 28.9 ± 4.0 kg, <i>p</i> = 0.010), and right HGS (35.6 ± 5.3 vs. 30.9 ± 4.3 kg, <i>p</i> = 0.009) than men carrying the A allele. The genotype differences in ASM (<i>p</i> = 0.017), ASM/height<sup>2</sup> (<i>p</i> = 0.011), lean mass (<i>p</i> < 0.001), left HGS (<i>p</i> = 0.010), and right HGS (<i>p</i> = 0.009) remained significant even after adjusting for all measured covariates. By contrast, no significant differences in other measured parameters were found between women carrying the A and C alleles. <b>Conclusions:</b> Our study findings indicate that the m.1382A>C polymorphism may be used as a genetic biomarker of age-related sarcopenia in older Korean men.
Study Information
pubmed
2024
2024-10-18T00:00:00.000Z
10.3390/biomedicines12102384
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