Mots-C
Mitochondrial open reading frame of the 12S rRNA-c, MT-RNR1, Mitochondrial-derived peptide MOTS-c
Exercise and vascular function in sedentary lifestyles in humans.
Fasipe. Babatunde B; Li. Shunchang S; Laher. Ismail I
Key Findings
- Sedentary behavior raises oxidative stress, damages endothelial function, and reduces NO production
- Moderate exercise activates NRF2 via ROS, helping reduce oxidative stress
- High‑intensity interval training boosts NRF2 even more by lowering KEAP, offering greater vascular benefits for inactive people
Practical Outcomes
- Incorporate regular moderate activity or short bursts of high‑intensity interval training to improve blood‑vessel health and counteract the damage from a sedentary lifestyle.
Summary
This review explains how sitting too much harms blood vessels by increasing oxidative stress and lowering nitric‑oxide, and how regular or high‑intensity interval exercise can reverse these effects by activating protective NRF2 pathways.
Abstract
People with sedentary lifestyles engage in minimal or no physical activity. A sedentary lifestyle promotes dysregulation of cellular redox balance, diminishes mitochondrial function, and increases NADPH oxidase activity. These changes collectively increase cellular oxidative stress, which alters endothelial function by oxidizing LDL-C, reducing NO production, and causing eNOS uncoupling. Reduced levels of nitric oxide (NO) leads to vasoconstriction, vascular remodeling, and vascular inflammation. Exercise modulates reactive oxygen species (ROS) to modify NRF2-KEAP signaling, leading to the activation of NRF2 to alleviate oxidative stress. While regular moderate exercise activates NRF2 through ROS production, high-intensity intermittent exercise stimulates NRF2 activation to a greater degree by reducing KEAP levels, which can be more beneficial for sedentary individuals. We review the damaging effects of a sedentary lifestyle on the vascular system and the health benefits of regular and intermittent exercise.
Study Information
pubmed
2023
2023-06-05T00:00:00.000Z
10.1007/s00424-023-02828-6
15
121