Mots-C
Mitochondrial open reading frame of the 12S rRNA-c, MT-RNR1, Mitochondrial-derived peptide MOTS-c
Mitochondrial Open Reading Frame of the 12S rRNA Type-c: Potential Therapeutic Candidate in Retinal Diseases.
Mohtashami. Zahra Z; Singh. Mithalesh Kumar MK; Neto. Farid Thomaz FT; Salimiaghdam. Nasim N; Hasanpour. Hossein H; Kenney. M Cristina MC
Key Findings
- MOTS‑c acts as a stress‑response messenger between mitochondria and the nucleus.
- In lab studies, MOTS‑c helped oxidatively stressed retinal pigment epithelial (RPE) cells survive.
- The peptide is proposed as a potential therapy for age‑related retinal diseases such as glaucoma, diabetic retinopathy, and AMD.
Practical Outcomes
- For biohackers interested in eye health, MOTS‑c is a promising target but still experimental. At this stage the best actionable step is to monitor emerging clinical trials or supplement research for safe ways to raise MOTS‑c levels (e.g., through exercise, fasting, or specific nutraceuticals that may up‑regulate its expression). No proven dosage or protocol exists yet, so caution and waiting for more data are advised.
Summary
MOTS‑c is a tiny protein made by mitochondria that helps cells cope with stress. Early research shows it can protect eye cells that are damaged by oxidation, which is linked to aging‑related eye diseases like macular degeneration, diabetic retinopathy, and glaucoma. The review suggests that boosting MOTS‑c could become a new way to keep the retina healthy, but real‑world dosing or treatment plans haven’t been worked out yet.
Abstract
Mitochondrial open reading frame of the 12S rRNA type-c (MOTS-c) is the most unearthed peptide encoded by mitochondrial DNA (mtDNA). It is an important regulator of the nuclear genome during times of stress because it promotes an adaptive stress response to maintain cellular homeostasis. Identifying MOTS-c specific binding partners may aid in deciphering the complex web of mitochondrial and nuclear-encoded signals. Mitochondrial damage and dysfunction have been linked to aging and the accelerated cell death associated with many types of retinal degenerations. Furthermore, research on MOTS-c ability to revive oxidatively stressed RPE cells has revealed a significant protective role for the molecule. Evidence suggests that senescent cells play a role in the development of age-related retinal disorders. This review examines the links between MOTS-c, mitochondria, and age-related diseases of the retina. Moreover, the untapped potential of MOTS-c as a treatment for glaucoma, diabetic retinopathy, and age-related macular degeneration is reviewed.
Study Information
pubmed
2023
2023-02-18T00:00:00.000Z
10.3390/antiox12020518
4
135