Mots-C
Mitochondrial open reading frame of the 12S rRNA-c, MT-RNR1, Mitochondrial-derived peptide MOTS-c
The Role of Peptide Hormones Discovered in the 21st Century in the Regulation of Adipose Tissue Functions.
Kołodziejski. Paweł A PA; Pruszyńska-Oszmałek. Ewa E; Wojciechowicz. Tatiana T; Sassek. Maciej M; Leciejewska. Natalia N; Jasaszwili. Mariami M; Billert. Maria M; Małek. Emilian E; Szczepankiewicz. Dawid D; Misiewicz-Mielnik. Magdalena M; Hertig. Iwona I; Nogowski. Leszek L; Nowak. Krzysztof W KW; Strowski. Mathias Z MZ; Skrzypski. Marek M
Key Findings
- MOTS‑c and other 21st‑century peptides can modulate white and brown adipogenesis
- These peptides affect fat cell function in vitro and in vivo
- Research points to potential roles in energy balance and metabolic regulation
Practical Outcomes
- MOTS‑c looks promising for influencing fat metabolism, but the review doesn’t give dosing or protocol details. Enthusiasts might consider it a candidate for future supplementation trials, while awaiting more concrete human data.
Summary
The paper reviews new peptide hormones, including MOTS‑c, that affect how fat cells grow and work. It shows that these molecules can influence both white fat (energy storage) and brown fat (energy burning) in lab and animal studies, suggesting they might help with weight and metabolic health.
Abstract
Peptide hormones play a prominent role in controlling energy homeostasis and metabolism. They have been implicated in controlling appetite, the function of the gastrointestinal and cardiovascular systems, energy expenditure, and reproduction. Furthermore, there is growing evidence indicating that peptide hormones and their receptors contribute to energy homeostasis regulation by interacting with white and brown adipose tissue. In this article, we review and discuss the literature addressing the role of selected peptide hormones discovered in the 21st century (adropin, apelin, elabela, irisin, kisspeptin, MOTS-c, phoenixin, spexin, and neuropeptides B and W) in controlling white and brown adipogenesis. Furthermore, we elaborate how these hormones control adipose tissue functions in vitro and in vivo.
Study Information
pubmed
2021
2021-05-17T00:00:00.000Z
10.3390/genes12050756
32
166