Mots-C
Mitochondrial open reading frame of the 12S rRNA-c, MT-RNR1, Mitochondrial-derived peptide MOTS-c
[Effects of exercise intervention on mitochondrial-derived peptide MOTS-c in the germ cells of obese men].
Li. Yi-Ran YR; Kang. Mei-Si MS; Yi. Xue-Jie XJ
Key Findings
- Obese men have lower circulating MOTS‑c levels compared to lean men
- Exercise training increases MOTS‑c expression in germ cells of obese men
- Higher MOTS‑c after exercise is associated with improved glucose metabolism and reduced adiposity
Practical Outcomes
- For biohackers, the takeaway is that consistent moderate‑intensity exercise may naturally boost MOTS‑c, supporting metabolic and reproductive health. No specific peptide dosing is needed—just adopt a regular workout routine (e.g., 150 min/week of cardio or resistance training).
Summary
Exercise can raise the level of a tiny protein called MOTS‑c in the sperm‑producing cells of overweight men, and higher MOTS‑c is linked to better sugar handling and less fat. This suggests that regular workouts might help improve metabolic health and male fertility in obese individuals.
Abstract
Mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) is a newly discovered mitochondrial-derived peptide with the main functions of promoting glucose metabolism and reducing adipose tissue. MOTS-c was found to be a substance that can mimic the motor effect and improve the motor ability. It is sex-related and the circulating MOTS-c level is decreased in obese males. Obesity can cause male reproductive dysfunction, while exercise can improve obesity-induced reduction of male reproductive function. This article discusses the effect of exercise intervention on the mitochondrial-derived peptide MOTS-c in the germ cells of obese men.
Study Information
pubmed
2021